Lege biomatrix

Tidens bioanalytyske stúdzjes, foaral as massaspektrometry-basearre metoaden wurde brûkt, moatte matrix-effekten wurde evaluearre. Foar beoardieling fan matrix-effekten, ADA-stúdzjes en relatearre ûndersyk, binne lege biologyske matriksen fan op syn minst 6, 10 of 50 yndividuele donateurs of batches faak ferplicht.
IPHASE stipet ynnovatyf medisynûndersyk foar lytse molekulen, peptiden, antykladen en ADC's mei wirklike biologyske matriksen sammele út mingd-seksdonors, mingde single-sekspools, of single-seks single donors. Wy leverje ek alternative matriksen, keunstmjittige matriksen en simulearre matriksen foar endogene analytestúdzjes, lykas matriksen dy't útput binne fan spesifike komponinten foar ûndersyk nei endogene stoffen.

DierSoarten

Cynomolgus aap, rhesus aap, marmoset, Beagle hûn, SD rat, Wistar rat, Wistar Han rat, ICR/CD-1 mûs, C57BL/6J mûs, C57BL/6N mûs, BALB/c mûs, BALB/c neaken mûs, Nu/Nu neaken mûs, NSG mouse, NSG mouse, NSG- CB17-SCID-mûs, Transgene mûs, Hamster (Gouden Syrysk), Guinea pig (Hartley), gerbil, katoenen rat, Bama miniature pig, Göttingen minipig, Nij-Seelânsk konijn, Feline, Bovine, skiep, fret, en mear

BioMatrix Kategoryen

1. 1. Native / Collected Matrices

Serum, plasma, folslein bloed, cerebrospinale floeistof, gal, molke, wetterige floeistof, vitreous humor, urine, maag sap, intestinal sap, synovial floeistof, feces, synovium, adipose weefsel, sciatic nerve weefsel, spier weefsel, skeletal spieren weefsel, gastrocnemius weefsel, harsens weefsel, lever weefsel, corne weefsel weefsel, intestinal weefsel vascular weefsel en weefsel homogenizes

• 2. IgG-depleted biologyske matrices

IgG-depleted serum/plasma, IgM-depleted serum/plasma, IgA-depleted serum/plasma, IgE-depleted serum/plasma, IgD-depleted serum/plasma

1. B. Komplement-depleted serum

C1q-depleted serum, C2-depleted serum, C3-depleted serum, C4-depleted serum, C5-depleted serum, C6-depleted serum, C7-depleted serum, C8-depleted serum, C9-depleted serum, C3/C4-depleted serum, C3/C4-depleted serum, C3/C4 Komplementfaktor D-depleted serum, Komplementfaktor H-depleted serum, Komplementfaktor I-depleted serum, Komplementfaktor P-depleted serum, C1q + komplementfaktor D-depleted serum, C3 + komplementfaktor B-depleted serum, C4 + komplementfaktor B-depleted serum, C5 + complement factor B-depleted

1. C. Lipoprotein-depleted serum/plasma

Lipoproteïne mei lege tichtheid (LDL)-depleted serum/plasma, Hiel leech-tichtens lipoproteïne (VLDL)-depleted serum/plasma, High-density lipoprotein (HDL)-depleted serum/plasma, Oxidized lipoprotein-depleted serum/plasma, Labeled lipoprotein-depleted serum/plasma

1. D. Vitamine-, hormoan- en aminosoeren-depleted serum/plasma
   • Vitamine D-depleted serum/plasma, Vitamin A (retinol)-depleted serum/plasma, Vitamin K-depleted serum/plasma, Vitamin E -depleted serum/plasma, Vitamin B-depleted serum/plasma, Catecholamin-depleted serum/plasma, Steroid-depleted serum/plasma, serum/plasma, Amino acid-depleted serum/plasma

1. E. Purified proteins

• Purified IgG, Purified IgM, Purified IgA, Purified IgE, Purified IgD, Purified albumine, Purified high-density lipoprotein (HDL), Purified low-density lipoprotein (LDL), Purified very low -

3. 3. Artificial / Simulated / Alternative Matrices

Keunstmjittich plasma, keunstmjittich serum, keunstmjittich folslein bloed, keunstmjittige cerebrospinale floeistof, keunstmjittige urine, keunstmjittige wetterige floeistof, keunstmjittige glêstried, keunstmjittige darmsop en keunstmjittige magesap.