Kashi S9 na hanta: Inganci a cikin binciken magunguna & S9 metabolic

Kalmomi masu mahimmanci:Kashi na S9, yanki na S9, gubar mahaifa, gyaran hanta, na hanta, na motsa jiki, juye juye-jita, s9 m metabolicy, s9 m metabolicy, s9 merabolicy

1 kayayyakin kayayyaki

2 A cikin karatun ƙwayoyin cuta na Vitro

A cikin binciken daidaitawar Vitro na vitro na Introcolistic yana nufin gwada yawan mahaɗan biotransptions a cikin matrixes na halittu, S9, kuma sel na hanta, don nuna yiwuwar pk na mahadi a vivo da ranarAdme, cimma ɗaukar hoto - Abubuwan da ke nuna alamun mahadi, da kuma hango ƙararrakin ɗan adam. Dangane da ka'idodin FDA,A cikin metabolism metabolismKaratun na bukatar amfani da jujjuyawar bayyanar danshi na microsomes (HLM), kwayoyin hanta na p450 (sabo ne ko kuma enzen), da enzen) don tantance hanyoyin rayuwa.

3 s9 s9 s9 s9 s9 / hepatic s9 kashi

DaKashi S9 (Tsarin S9)Shin Mitochondria kyauta ce ta 'yan kwayar sel na hanta homogenate, dauke da babban adadin cyps da sauran enzymes enzymes. Kayan aiki ne mai amfani sosai don nazarin metabolism miyagun ƙwayoyi da bincika yuwuwar miyagun ƙwayoyi - Cikakken miyagun ƙwayoyi. Hakanan mahimmancin mai mahimmanci ne ga kimantawa na gwajin cututtukan mutarcical (Ameurs) da gwaje-gwaje, kayan kwalliya, qwari, da sauran filayen. A cikin gwajin kwanciyar hankali na rayuwa, ana amfani da s9 a yawancin wurare masu zuwa:

Rashin ingancin CLECE: Wannan muhimmiyar nuna alama ce don kimanta ayyukan enzyme a cikin shirye-shiryen hanta. Misali, a cikin jikin mutum, samar da yanayin hanta s9 kusan 634, wanda ke nuna cewa hanta S9 ya sami ingantaccen ikon rayuwa.

Shiri na metabolite: shirye-shiryen hanta S9 na S9 zai iya metabolize daban-daban mahaɗan kuma samar da metabolites daban-daban. Motsa na waɗannan metabolites yana da mahimmanci don fahimtar hanyoyin da na rayuwa da kuma ayyukan kwayoyi na kwayoyi.

Binciken Phenabolent na rayuwa: kwanciyar hankali na metabolicy na kwayoyi, gami da ci gaba na rayuwa da kuma yawan hulda da miyagun ƙwayoyi, ana iya yin nazari ta hanyar shirye-shiryen hanta na hanta.

4 gungun S9 na hanji

Hanji s9 s9 shine bangaren lantarki /subcelulular jujiAn shirya daga nama na ciki, wanda ya kunshi yawan miyagun ƙwayoyi masu yawan ƙwayoyi (kamar cyp3a4, Ult, kisan kiyashi da sufuri. Ana amfani da shi don yin nazarin na farko - sama metabolism na baka magunguna da kuma tasirin synergistic na metabolism sha ɗaukar ciki metabolik. Aikace-aikacen sa sun haɗa da kimanta maganin ƙwayar ƙwayar magunguna a cikin gut (kamar sulhu na magana), da kuma gano gudundiddigar da na gut metaboles (kamar sult1b1).

5 sauran murhun hanji

Lung S9, Koda S9, da fata S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 S9 An samo su ne daga kyallen kyallen takarda da kuma nazarin kayan metabolism na gida.

Lung s9 ctionirgar: dauke da cyp1a1 / 2, ana amfani da shi don kimantaccen magunguna na ƙwayar cuta ko gurbatawar muhalli;

Kawar Koda S9(Kashi na Kinal (Kaya S9): dauke da UGT da kuma sakewa, kimanta kariya na ramuka da ƙarni na nephrotoxic metabolites;

Kashi s9 na fata: Yi nazarin kwanciyar hankali na metabolic na magunguna masu canzawa da kuma kunna enzymes fata (kamar sult1e1).

Wadannan kayan haɗin S9 S9 don iyakancewar bayanan na metabolic ta hanyar simulating nama - takamaiman mahalli na rayuwa.

6 daban-daban nau'in s9

Tsarin aikin na metabolic a cikin gwajin cututtukan cututtukan cututtuka shine hade da maganin hanta S9 da kuma cofactors da aka shirya daga hanun dabba bayan an shirya magani. A halin yanzu, bambance-bambance a cikin kwanciyar hankali da kuma bayanan martaba na meto. Rodent jinsin da ba - nau'in rodent waɗanda suke da halayyar mafi kusa ga mutane na mutane. Saboda haka, a zabin kayan gwaji don hanta s9, wanda ya fi dacewa da shiKashin kai na ɗan adam S9, yanki na danshi na Monkey, mai kare hancin hanta s9 s9 s9 s9 s9 ctionirgin hanta,dalinzarsa mai motsi s9

7 Gaba

Abubuwan haɗin S9 (ciki har da s9, hanji s9, huhu s9, koda da fata s9mating s9me s9me) sune mahimman bayanai game da haɓakar ƙwayoyin enzyme da kuma yanayin rayuwa daban-daban. Dan wasan na S9, tare da enzymes na metaboles mai kamar cyps da cinya, ana amfani da su sosai don yin ƙididdigar kwastomomi, ganowar metabolite, da bincike na metirsification; Hanji s9 na hanji a kan farkon wucewar farko metabolism da shan mamakin metabolgy na baka magunguna; Kuma huhu s9, koda S9, da fata S9 na S9 na iya kimanta kantin kwayoyin halittar da guba, cika iyakokin nau'ikan metabolism na hanta. Bugu da kari, karatun m a ko'ina cikin jinsuna na S9 (kamarKarkashin hanta na ɗan adam, digo na S9, De De Dec Forction Forction, Rat S9 s9 s9 s9 s9 cractions da haɓaka ƙimar gwaje-gwaje na bayanai.