Loaʻa iā mākou kahi loea, limahana kūpono e hoʻolako i ka lawelawe kiʻekiʻe no kā mākou mea kūʻai. Ke hahai mau nei mākou i ka ʻōlelo a ka mea kūʻai - pili, kikoʻī - nānā ʻia no ka monkey-serum-kit,ʻīlio PBMC pahu, NHP PBMC kime, pahu microsomes māmā, puʻupuʻu hakina S9. Manaʻo mākou iā ʻoe e nīnau mai iā mākou ma ke kelepona a i ʻole ka leka uila a manaʻolana e kūkulu i kahi pilina kūleʻa a hui pū. ʻO ka hopena, ua loaʻa iā mākou kahi pūnaewele kūʻai honua a hiki i ka Middle East, Turkey, Malaysia a me Vietnamese.pahu microsomes ʻōpū, moltox s9 kime, puʻupuʻu hakina S9, pahu minipig PBMC.
Ma muli o ka emi ʻana o ka hana o ka enzyme metabolizing i ka lāʻau me ka hoʻolōʻihi ʻia o ka manawa incubation in vitro, loaʻa i nā hiʻohiʻona kuʻuna in vitro metabolism nā palena e like me ka manawa incubation pōkole.
ʻO Micronuclei nā chromatids holoʻokoʻa a i ʻole nā ʻāpana acentric a i ʻole nā chromosomes apo e mau ana i loko o ka cytoplasm ke komo mau nā chromosomes i nā keena kaikamahine e hana i ka nuclei ma hope o ka mitosis.
PDC in vitro ADME noiʻi kŘkohu PDC e noʻonoʻo i nā hiʻohiʻona o nā molela nui a me ka liʻiliʻi. No laila, pono e noʻonoʻo i ka noiʻi in vitro ADME e pili ana i ka homing peptides, linke
ʻO ka hoʻokaʻawale ʻana o Peripheral Blood Mononuclear Cells (PBMC) he hana koʻikoʻi i ka noiʻi biomedical a me nā noi lapaʻau. Loaʻa i kēia mau pūnaewele nā lymphocytes (e laʻa, T cell, B cell, NK cell) a
Ua hoʻohana nui ʻia ka in vivo alkaline comet assay i ka loiloi genotoxicity o nā pūhui. Ua hoʻokomo ʻo ICH S2(R1) i ka hoʻāʻo ʻana o ka comet ate ma ke ʻano he 2nd in vivo hoʻāʻo no nā kiko/hopena; he
Loaʻa i ka hui nā waiwai waiwai, nā mīkini holomua, nā limahana akamai a me nā lawelawe maikaʻi loa, manaʻolana ʻoe e hoʻomau a hoʻomaikaʻi i kāu huahana a me kāu lawelawe, makemake ʻoe e ʻoi aku ka maikaʻi!
ʻO ka pili ʻana i ka loina ʻoihana o nā pōmaikaʻi like ʻole, loaʻa iā mākou kahi ʻoihana hauʻoli a kūleʻa, manaʻo mākou e lilo mākou i hoa ʻoihana maikaʻi loa.
Loaʻa i ka luna o ka ʻoihana ka ʻike hoʻokele waiwai a me ke ʻano koʻikoʻi, ʻoluʻolu a hauʻoli nā limahana kūʻai aku, ʻoihana ʻenehana a kuleana, no laila ʻaʻohe o mākou hopohopo e pili ana i ka huahana, kahi mea hana maikaʻi.
He nui nā koho i hoʻomākaukau ʻia e kēia hui e koho ai a hiki nō hoʻi ke hana i ka papahana hou e like me kā mākou makemake, he mea maikaʻi loa ia e hoʻokō i kā mākou pono.