Noʻonoʻo ʻo PDC i nā ʻano o nā molekala nui a me nā mole liʻiliʻi.No laila, pono e noʻonoʻo i ka noiʻi in vitro ADME e noʻonoʻo i nā peptides homing, nā loulou, nā uku, a me ka PDC.I ka hoʻomaka ʻana o ka hoʻomohala ʻana i ka lāʻau lapaʻau, inā ʻo ka homing peptide i ke ʻano o kahi lāʻau polypeptide, ua maʻalahi ia i ka hydrolysis a ʻaʻohe paʻa. Pono e noʻonoʻo ʻia kona kūpaʻa a me ka huli ʻana i ka plasma; i ka manawa like, e hoʻopuka nā ʻano ʻelua o ka mea hoʻopili i nā hopena metabolic like ʻole, a ʻo ka uku i hoʻokuʻu ʻia (me ka uku i hoʻopili ʻia i ka ʻāpana like o ka linker) he lāʻau cytotoxic liʻiliʻi. He mea koʻikoʻi ka hoʻoholo ʻana i nā metabolites o kēia mau lāʻau no ka hoʻomohala ʻana i ka lāʻau. No laila, pono e aʻo ʻia ka PDC me nā peptides homing, nā loulou, a me nā uku i ka paʻa o ka plasma, ka paʻa ʻana o ka protein plasma, ka ʻike metabolite, a me nā mea ʻē aʻe, he mea nui ia no ka hoʻomohala mua ʻana o nā lāʻau PDC!
IPHASE "Hoʻokahi - kū" ka hopena huahana no ka noiʻi in vitro DMPK
Ma ke ʻano he alakaʻi i loko o ka noiʻi in vitro biological reagents, hahai ʻo IPHASE i ka mua o ka hoʻomohala ʻana i ka lāʻau lapaʻau a hoʻomohala i nā ʻano like ʻole in vitro biological reagents ma nā pae he nui a me nā kahua e kuhikuhi ana i ka in vitro DMPK kuhikuhi noiʻi o nā lāʻau PDC e kōkua i ka noiʻi hoʻomohala lāʻau PDC!
1. Subcellular fraction reagents
·Nā microsomes ate ·A'o S9/ Aʻaʻawaʻawa S9
·Cytosol ate ·Kiʻi S9
·Lysosome · Acidified ate homogenate
2.Primary Hepatocyte Products
· Kanaka/Monkey/ʻIlio/ʻIole/ʻiole/Minipig i hoʻopaʻa ʻia/Adherent PrimaryHepatocytes
3. Nā mea lawe lawe
· Nā mea lawe ʻohana ABC ·SLCnā mea lawe ʻohana
4.Recombinant enzyme huahana
·CYP ·UGT
5.Plasma nā huahana pili
· Equilibrium dialysis lako · Plasma stability test products
· ʻO nā mea hoʻopaʻa hoʻopaʻa i ka protein plasma
6.Blank biological matrix
Ka manawa hoʻouna: 2024-08-16 15:26:10