Companylọ ọrụ anyị na-arụ ọrụ ugbu a n'ihe fọrọ nke nta ka ọ bụrụ na mpaghara 40 ma were ihe dị ka mmadụ 10000 n'ofe ụwa niile, anyị bụ ndị ama ama na mba ụwa ma nwee ahụmịhe teknụzụ na òké - eriri afọ - microsomes,homogenate nke eriri afọ, Streptavidin magnetik beads, eriri ọbara mononuclear cell, Comet Assay slide. Anyị na-ewere onye ọrụ mgbe niile ka etiti. Anyị na-aga n'ihu na-emepụta ihe ọhụrụ. Anyị na-agbaso echiche ọhụrụ, ihe ọhụrụ mbụ, nkwakọ ngwaahịa ọhụrụ, ntinye ihe ọhụrụ. Anyị na-aga n'ihu na-emeziwanye asọmpi nke ụlọ ọrụ.N'ime afọ, anyị na-ewere "afọ ojuju ndị ahịa" dị ka ọrụ anyị ma na-enye ndị ahịa ọrụ ọrụ ọkachamara "na-arụsi ọrụ ike, ọkọlọtọ, nlezianya na nke ọhụrụ". Anyị na-atụgharị "ịdị mma ngwaahịa" na "ịdị mma ọrụ" ka ọ bụrụ omume bara uru. Anyị na-enye gị oge na-echegbu onwe - ọrụ ịre ahịa n'efu n'oge usoro a, ka ọ na-ewetara gị ọrụ mmekọrịta chiri anya iji bulie uru. Kwa afọ, ụlọ ọrụ ahụ na-etinye ego na nyocha na mmepe nke ngwaahịa ọhụrụ, jikọtara ya na usoro mba ụwa. Anyị na-abanye n'ime echiche imewe anyị, nke mere na ngwaahịa anyị na-adị mgbe niile na ọkwa kachasị elu iji zute usoro ndị ahịa ahịa nke ụlọ maka.ngwa mgbasa ozi omenala cell, Tissue ara, mmadụ CBMC, vitreous ọchị.
Okwu mmalite nke oke imeju S9 Rat Imeju S9 bụ obere akụkụ cellular enwetara site na anụ ahụ imeju, ọkachasị site na oke oke, na-agbaso otu usoro homogenization na centrifugation. O nwere a
IPHASE, dị ka onye ndu na ndu reagents maka in vitro nnyocha nke ọhụrụ ọgwụ, na-aga n'ihu na-ewebata elu - ọgwụgwụ nnyocha reagents n'ọtụtụ ubi na ụdị dabere na afọ nke nnyocha na mmepe ahụmahụ.
● Mmalite nke nnwale chromosome aberration Nnwale chromosome aberration bụ ngwa dị mkpa na nyocha mkpụrụ ndụ ihe nketa na nyocha ụlọ ọgwụ. Emebere ule ndị a iji chọpụta na mara nhazi
Mwepu nke mkpụrụ ndụ ọbara mononuclear (PBMC) bụ usoro dị oke mkpa na nyocha biomedical na ngwa ụlọ ọgwụ. Selụ ndị a gụnyere lymphocytes (dịka, mkpụrụ ndụ T, sel B, sel NK) a
Ebe ọ bụ na ọgwụ metabolizing enzyme ọrụ ji nwayọọ nwayọọ na-ebelata site na ịgbatị oge in vitro incubation, ụdị ọdịnala in vitro metabolism nwere oke dị ka oge nnabata dị mkpụmkpụ.
The in vivo alkaline comet assay na-ejiwanye na nyocha nke genotoxicity nke ogige. ICH S2 (R1) agụnyela imeju comet assay dị ka 2nd in vivo test for tissues/ endpoints; ihe
Anyị na-atụ anya na ụlọ ọrụ gị nwere ike ịnọgide na-enwe ya mbụ ebumnobi, na anyị mgbe niile na-atụ anya ịnọgide na enyi na enyi imekọ ihe ọnụ na-achọ ọhụrụ mmepe ọnụ.