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The in vivo alkaline comet assay has been increasingly used in the genotoxicity evaluation of compounds. ICH S2(R1) has included the liver comet assay as the 2nd in vivo test for tissues/endpoints; an
With the continuous development of biotechnology, the development of targeted antitumor drugs such as small molecule compounds, oligonucleotides and biologics has made rapid progress, among which siRN
The isolation of Peripheral Blood Mononuclear Cells (PBMC) is a crucial technique in biomedical research and clinical applications. These cells include lymphocytes (e.g., T cells, B cells, NK cells) a
Introduction to Liver Microsomes
Microsomes are small vesicular fragments derived from the endoplasmic reticulum and are found within liver cells (hepatocytes). They play a crucial role in various bio
Introduction to mRNA drugs Messenger RNA (mRNA) is a sequence of nucleotides that encodes a protein, and in the cytoplasm is able to use organelles to express the encoded protein. mRNA drugs are chemi
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