News
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Artificial Cerebrospinal Fluid(CSF) Matrix for Cross-Species CNS Drug Testing
Keywords: Cerebrospinal Fluid, Artificial Cerebrospinal Fluid, Artificial CSF, Simulated Cerebrospinal Fluid, Simulated CSF, CSF Sample, LC-MS/MS, Human CSF, Cynomolgus Monkey Cerebrospinal Fluid (CSFRead more -
5α-Reductase Activity Study: SRD5A1 & SRD5A2 for Sebum Control in Cosmetic Science
Keywords: Type 1 5α-Reductase, Type 2 5α-Reductase, 5αR1, 5αR2, SRD5A1, SRD5A2, NADPH, 5α-Reductase Activity, 5α-Reductase Inhibition, Dihydrotestosterone(DHT). IPHRead more -
Induced Rat Liver S9 Fraction: A Metabolic Activation System for In Vitro Genotoxicity and Mutation Tests
Keywords: OECD 471, OECD 473, OECD 476, OECD 487, Mutation Test, Genotoxicity, Genetic Toxicity, Induced Rat Liver S9, Ames Test, Mini Ames Test, Chromosomal Aberration, Micronucleus, HPRT/HGPRT AssayRead more -
Understanding the Role of Induced S9 Fractions in Drug Metabolism Studies
In vitro models have become indispensable in modern toxicology and pharmacokinetics, particularly when assessing how a compound behaves metabolically before progressing to in vivo stages. One widely aRead more -
Plasma Protein Binding Dynamics: Equilibrium dialysis and Ultrafiltration Methods and Application in DDIs
Keywords: Equilibrium Dialysis, Ultrafiltration, Plasma Protein Binding(PPB), Binding rate of plasma protein(BRPP), Equilibrium Dialysis Device, Equilibrium Dialysis Membrane, Rapid Equilibrium DialysRead more -
IPHASE Bioscience Showcases Innovative ADME-Tox Solutions at Lunch & Learn Event in Doylestown
IPHASE Biosciences Showcases Innovative ADME-ToxSolutions at Lunch & Learn Event in Doylestown On April 9th, IPHASE Biosciences held a successful Lunch and Learn event at Pennsylvania Biotechnology CRead more -
Transporters and Their Roles in Pharmacology
Transporters and Their Roles Transporters are a broad class of transmembrane proteins that span the cell membrane of many tissues and play an essential role in controlling the passage of endogenous (nRead more -
Hepatocytes in Drug Metabolism and siRNA Drug Delivery: Evaluating Model Systems Across Species
Keywords: Hepatocytes, Primary Hepatocytes, Plateable Hepatocytes, Suspension Hepatocytes, Hepatocytes Metabolic Stability, Hepatotoxicity, CYP450 Enzyme Induction, Primary HumanHepatocytes(PHH), PrimRead more -
What Are Human PBMCs and Their Role in Immunity?
Human PBMCs, or Peripheral Blood Mononuclear Cells, are a critical group of immune cells that circulate in your bloodstream. These cells include lymphocytes, monocytes, and dendritic cells, each playiRead more -
Introduction and Concepts of siRNA Drug (Oligonucleotides)
Background By virtue of its unique technical characteristics, siRNA Drug has become the focus of attention in the field of new drug research and development in recent years, and is one of the most rapRead more -
Splenocytes in Immunological Research: Across Species and Isolation, Freezing, Thawing Steps
Keywords: Splenocytes(SPLs); Cynomolgus Monkey Splenocytes; Rhesus Monkey Splenocytes; Dog Splenocytes; Canine Splenocytes; Rat Splenocytes; Mouse Splenocytes; Mice Splenocytes; Rabbit Splenocytes; SpRead more -
Optimizing PBMC Isolation: Best Kits for High Purity Results
Peripheral Blood Mononuclear Cells (PBMCs) are widely used in biomedical research, playing a crucial role in fields such as immuno-oncology, biomarker discovery, drug development, and cell therapy. ThRead more