Litharollo tsa Lithethefatsi tsa Sirna ho Vitra Metabolism Pajana

Litharollo tsa Lithethefatsi tsa Sirna ho Vitra Metabolism Pajana

Lithethefatsi tsa nyutlelie acid, ka lebaka la litšobotsi tsa tsona tse ikhethang tsa theknoloji, e se e le mohopolo oa ntlafatso e ncha ea lithethefatsi lilemong tsa morao tjena. Lithethefatsi tsa Nucleic Acid li kenyelletsa rna (Sirna), Ogoligonucleotides (Mirna), Mefuta ea Li-conjoduotes. Har'a tsena, lithethefatsi tsa Sirna, joalo ka hotse ea sethethefatsi le nts'etsopele ea lithethefatsi tse ncha tsa lithethefatsi ka lebaka la mokhahlelo oa tsona oa lithethefatsi, litlatsetso tse laoloang. Li lebelletsoe ho ba litlhare tse tšebelisano ka ho fetisisa bakeng sa ntlafatso e ncha ea lithethefatsi kamora molek'hule e nyane le lithethefatsi tsa antibody.

1. 1. Mochine oa Mechanistics ho ketso ea lithethefatsi tsa Sirna

Rna (Sirna), e boetse e ratile RNA, RNA e khuts'oane ea RNA. Ho Synthesis, Sirna o kena selekaneng ka andoctosis. Karolo ea Sirna e pholohela mokhoa oa boikhathollo oa siGsosal 'me o kena cytoplasm, moo e kenngoeng RNA - Sant Cancing rass (RSC). Ka har'a Risc, Sirna e sekisoa ka mahlafo a le mong a le mong. Slind e sa utloahaleng e senyehile ka potlako Cytoplasm, ha a le kotsi, a tlameletsoe ho seteishene sa lithibela-khoela, se sebetsa. Ka hona, rarahane ka mokhoa o ikhethileng, o nolofalletsa sesepa sa eona le ho hlakisa ka mor'a nako e tlang. Ka lebaka la ho nyenyefatsa 'ho' boemong ba mofuta oa mofuta oa sepheo o fokotsehile haholo, qetellong o le ho khutsisa le ho khutsisa taeo ho a tanteng le ho thibela pele ho phetolelo ea protheine.

1. 2. Sirna siling ea lithethefatsi tsa metabolism

A Vivo, Sethethefatsi sa Sirna se fetisitsoe ke nyutlelie le liqoso tse teng ho li-plasma le lisele, ho fapana le ho tloha ka Plasmaties ka har'a sebete. Likhatiso tse latelang, ha joale lithethefatsi tse rekisoang hajoale li bontša metabolism hodima maling a mali. Ka tloaelo, boholo ba lithethefatsi tsa Sirna li hlahisoa ka potlako ke sebete, ka karoloana e nyane e ile ea ajoa ho lisele tse ling, moo li bileng teng ka mor'a moo. Bakeng sa lithuto tsa vivolilism tsa vivolism tsa lithethefatsi tsa Sirna Metabolic hangata li tsejoang le tse hlahlojoang ke li-plasma.

Leha ho le joalo, nakong ea kholo ea lithethefatsi, palo e kholo ea linako tse telele tsa liteko, le liphuputso tse phahameng tsa liteko tsa vivo e amanang le ho hlahlojoa ha vivo le ts'ebetso ea sebopeho. Ka lebaka leo, lithuto tsa vitra Metabolism tsa Mitrabolism li bohlokoa haholo lilemong tsa tlhahlobo ea lipalesa tsa Sirna ea Sirna. Lithuto tsena li fana ka melemo e tlase, tse kang tlhahiso e phahameng le potoloho e khuts'oane ea liteko tse ka ntlafatsang katleho ea ho hlahlojoa ha Sirna haholo.

Tafole ea 1: Ho Vitra Metabolism ea lipatlisiso bakeng sa lithethefatsi tsa Sirna

1. 3. Lihlahisoa tsa Iphase tse loketseng