One - STEP STOR STORIST ea sehlahisoa sa Vitradro Adme lithuto tsa lithethefatsi tsa ACSS

Phekolo ea Phetohelo: Antibody - Oheligonucleocide e kopanya (Aocs) - bokamoso ba meriana ea ho phela

Lefatšeng ka potlako e phelisang hantle ea biopharmaceutical,Antibody - Oligonucleotide Conjugoates (Aocs)li tsoa joaloka sehlopha sa litlhako tse kholo tsa lithethefatsi, li kopanya matla a hlahlobisisoang a li-antibodies tsa li-inntibodies tse nang le khahlano - aphaphabo la bokhoni. Litlhare tsena tse ncha li etselitsoe ho fana ka omoligonhletides - lisenthine tse khutšoane tsa DNA kapa Rna - lisele tse ikhethang, ho bolela ho hlaka ka kalafong. Khokahano ena - Ts'ebetso ea Ketso e Bulela menyetla e mecha ea ho sebetsana le maemo a thata joalo ka mofets'e, mathata a lefutso le mafu a ho itšireletsa mafung.

Hobaneng ha ao suc

Aocs e entsoe ka likarolo tse tharo tse mahlonoko: antibody, oligonucleode le linker. Kopano ena e ikhethang e hloka ho hlahloba tlhokomelo ka hloko nakong ea kholo, haholo lithutong tsa Phaskokic. Ho fapana le litlhare tsa setso tse nyane, Olinocleotides li nang le litšobotsi tse ikhethang - boima ba 'mino bo phahameng le ho li etsa hampe. Nts'etsopele ea morao-rao ea lithethefatsi, ke ea bohlokoa molemong oa boitšoaroLithuto tsa Plasma / Serum SlustHo netefatsa hore karolo ea Oligonucleotide e lula e tiile, kaha e angoa ke ho nyonyeha ke li-nyuclease. Ho tsitsa le ho lokolloa ha Oligocleocleotide ka lisele tse behiloeng ho bohlokoa bakeng sa katleho ea Aocs.

Ntle le moo, mokhoa oa ho kopanya oliligonhletide ho antibogment e amang maikutlo ka kotloloho hore lithethefatsi li lokollotsoe ka nepo joang ka har'a seleng, haholo-holo Lysosomes. Se etsahetseng hloko se bolela hore Aocs e hloka mekhoa e ikhethang ea lithuto tse bileng teng, tse etsang hore moralo oa bona le tlhahlobo ea bohlokoa ka katleho ea bona.


Ke OleskAndr Koniev - Mosebetsi oa hau, CC ka - SA 4.0

Iphase: Molekane oa hau ho ACOC Phano

Kholong e latelang ea leqhubu le latelang la nts'etsopele ea lithethefatsi tse latelang tsa lithethefatsi tse haufi le ho khaola - pheletsoka vitro bio - Reagents. Ka mofuta o felletseng oa bio - Lintlafatso, re thusa bafuputsi ho fihlela ho senya lefu la lithethefatsi le nts'etsopele. Sebaka sa rona se pharalletseng sa Redme sa Redme, se entsoe ka ho khetheha bakeng sa limolek'hule tse nyane, ho na le lithethefatsi tse ngata, li fana ka lisebelisoa tse hlokofatsang ho netefatsa katleho ntlafatsong ea lithethefatsi.

Ka lilemo tse ngata tsa boiphihlelo le boqapi, iphase e fana ka aSute Suite ea Lihlahisoa tsa Vitro tsa Vitrabakeng sa lithethefatsi tsa Aoc le haufi. Hore na o ntse o tsoela pele u ntse o tsoela pele, limolek'hule tse nyane, kapa sehlopha sefe sa lithethefatsi, Iphase e ikemiselitse ho fana ka tharollo eo u e hlokangkhanna patlisiso ea hau peleHape, tlisa moloko o latelang oa phekolo bophelong.

Fumana bokamoso ba nts'etsopele ea lithethefatsi ka iphase-Ke mabaka a bongaka hobane moriana o lokelang ho beha lisebelisoa tsa ho loka.