Kenyelletso eaLi-Microsomes
Microsomemes ke likotoana tse nyane tsa vesicular tse tsoang ho setumo sa endoplesmity mme li fumanoa ka har'a lisele tsa sebete (li-hepatocytes). Ba kenya karolo ea bohlokoa lits'ebetsong tse fapaneng tsa biochemical, haholo-holo ka metabolism le detexation. Ho utloisisa sebopeho, ts'ebetso le bohlokoa ba merero ea sebete ho bohlokoa ha ho hlokahala litlamorao tsa bona ho phepelo ea phetolelo, 'me ka botlalo sebete sa maiketsetso le sebete.
Sebopeho le sebopeho sa Microsomes
● Tšimolohe ho tloha ho endoplasmic
Microsomemes e thehoa nakong ea homogenization le e fapaneng ea lisele tsa sebete, moo ho iphetola ha endoplasmim le senya li-avesike tse nyane. Ts'ebetso ena e lumella ho itšehla thajana ho likarolo tsena tsa subcellmlem, e leng li-metaboli tse fapaneng tsa metabolic.
● Mokhatlo le morfanelogy
Li-Microsomem tsa sebete li nang le membrane - E ngolisoa li-enzyme, liphikiso le liprotheine. Sebopeho sa bona se ba nolofalletsa ho etsa karabelo e ngata ea biolopical ea biolomical, ho kenyelletsa le e kenyellelitsoeng ke lesira la cytochrome P450me tsamaiso ea enzchrome P4TYME. Libimetsi tsa morphological tsa Microsomes ke Pivotal ho tsebisang bokhoni ba tsona bo sebetsang tseleng ea metabolic litseleng tsa metabolic.
Microsomem le Metabolism ea lithethefatsi
● Karolo ea ho khelosa
Li-Microsomes tsa sebete li bohlokoa ho bokhoni ba 'mele ba ho tlosa metsoako e fapaneng, ho kenyelletsa le lithethefatsi le chefo ea tikoloho. Ts'ebetso ena ea boipheliso e kenyelletsa ho fetola lintho tse fetohang ka metsing ho feta moo ho ka qhibiliha habonolo 'meleng.
● Sisterm ea enzchrome p450
E 'ngoe ea likarolo tse nyarosang ka ho fetisisa kahare ho li-Microsomes tsa sebete ke cytochrome p450 (cyp) Sister Symzyme Sisterm. Ba-batona bana ba na le boikarabello ba metabolism ea subrate ea likarolo tse fapaneng, ho kenyelletsa meralo, ka hona ba bapala karolo ea bohlokoa ho metabolism ea lithethefatsi. Mosebetsi oa li-enzyme tsena o ka susumetsa ho sebetsa hantle le ho ntša metsi a ommeng meriana.
Mindomas e kenang le mesebetsi ea bona
● Mefuta ea li-enzyme e teng
Li-Microsomemes tsa sebete li na le mefuta e mengata ea li-enzyme tsa enzyme, ho kenyelletsa le li-oxidases, litlolo le hydrolase le hydrolase. Mofuta o mong le o mong oa enzyme o hlophisitsoe hantle ka ho fana ka karabelo e tobileng ea biochemical, e kenya letsoho ts'ebetsong ka kakaretso ea metabolic ea sebete.
● Ho arabela ka tsela e itseng ho ka sehl
Ebang ka har'a Micross Microsomems e fokotsang maikutlo Boitšoaro bona bo bohlokoa bakeng sa biotranforfl "metsoako ea metsoako ea mamello le ea Exogenus, e netefatsa tšebeliso ea bona e nepahetseng ea metabolical.
Karolo ho li-metabolism tsa Xenobiotic
● Ho putlama ha lintho tsa kantle ho naha
Microsomemes ke pivotal ho metaboolises - e leng lintho tse ling tse kenang 'meleng, tse kang lithethefatsi, li-coungcans le liporone. Ka letoto la liphetoho tsa enzzzy, Microsomes e fetola lintho tsena tse mpe tse kotsi ho isa ho le ho feta.
● Bohlokoa ho Phatlalatso ea PharmaCology le Toxicolover
Bokhoni ba Microsoomes ho Metabolize Xenobiotics e na le litlamorao tsa bohlokoa tsa meriana ea phetolelo ea phatlalatso le ho chefo ho chefo. Ketsahalo ea Minosal e thusa ho bolela litaba tse ling, litla-morao le phapang e ka bomong ea metabolism, maano a lithethefatsi.
Microsomemes in Lipid Metabolism
● Synthes ea Lipids
Li-Microsomes tsa sebete li bapala karolo ea bohlokoa ho metabolism ea metabolism, ho kenyelletsa le menyenyane ea phospholis le tlolo ea molao. Mepi ena ke likarolo tsa bohlokoa tsa membrane ea sele, 'me u sebeletsa e le bohlokoa ba merero ea merero ea ho boloka botsofali le matla a matla.
● Karolo ea k'holeseterole le metabolism ea steroid
Li-Microsomemes li kenya letsoho ho biolosynthesis le tsamaisong ea li-cholesterol le lihormone tsa steroid. Enzyme Micrososmes e tsamaisa phetoho ea cholesterol e bile lihomone tsa li-acidterol le liholeoe tsa striecile, tse bohlokoa bakeng sa ts'ebetso e fapaneng ea 'mele, ho kenyelletsa tšilafalo le bophelo bo botle.
TLHOKOMELISO EA METSOALLE EA METSOALLE EA MINROMAL
● Lintho tse amang mesebetsi ea enzymatic
Ho na le lintlha tse 'maloa tse ka susumetsang tšebetso e ntle ea microsal, ho kenyelletsa liphapang tsa lefutso, lilemo tsa batho, thobalano le maemo a lefu. Ho feta moo, lintho tsa ka ntle tse kang lijo, ho pepesetsoa tikoloho le ho ba teng ha lithethefatsi ka kakaretso le metabolism ea lithethefatsi.
● Ts'oero ea Lijo le Tikoloho
Metsoako ea lijo le lintlha tsa tikoloho li bapala karolo ea bohlokoa ho tsamaisa mosebetsi oa minosal. Mohlala, lijo tse itseng li ka susumetsa kapa ho thibela tšebetso ea cytochrome p450tome, e lebisang ho mefuta ea metabolism le ts'ebetso. Litefo tsa tikoloho le tsona li ka ama tšebetso ea microssal, e amang bokhoni ba sebete sa ho tima lintho tse mpe.
Phetoho ea bophelo bo fetoha ea Microsomes
● Sesebelisoa sa litsi tsa sebete
Mafu a Selth a kang hepatitis, cirhosis, le lefu le mafura a sebete le ka lebisa ho liphetoho mesebetsing le sebopeho sa enzsal minomal. Liphetoho tsena li ka fokolisa bokhoni ba sebete ba ho sebelisa metabolize ho sebelisa lithethefatsi le lintho tse ling, ho kenya letsoho tsoho ea lefu la sebete le nts'etsopele ea mathata.
● Liphetoho ka lebaka la tšebeliso e mpe ea joala kapa lithethefatsi
Tšebeliso e mpe ea joala le tlhekefetso ea lithethefatsi e ka hohela liphetoho tse kholo ho Microsomemes, ho kenyelletsa ho itšireletsa kapa ho thibela enzyme kapa thibelo. Liphetoho tsena li ka ama bokhoni ba sebete sa ho ea metabolize lintho tse ka bang ho bokellana le ho bokelloa le ho ba le tšenyo ea ho eketseha.
Microsomemes ka lipatlisiso le lingaka
● Sebelisa ka ho ithuta ho sebelisa lithethefatsi
Li-Microsomes tsa sebete li sebelisoa haholo lipatlisisong tsa khale tsa ho ithuta ts'ebelisano ea lithethefatsi le ho bolela litaba tse molemo ho bolela litaba tsa metabolisic. Bafuputsi ba sebelisa Microsomes ea sebete ho lekola bokhoni ba tšebeliso ea lithethefatsi, ba khetholla botsitso ba metabolication, le ho khetholla metaboolites, ho fana ka tlhaiso-leseling ea lithethefatsi le polokeho.
● Likopo ka li-diasical tsa bongaka
Ka li-dianical tsa bongaka tsa bongaka, lingaka tsa sebete li sebetsa e le sesebelisoa sa bohlokoa sa ho lekola ts'ebetso ea sebete le ho lemoha mafu a metabolic. Ho lekola Microsos ea sebete ho ka thusa ho khetholla bofokoli ba anzyme, ho tataisa likamano tsa kalafo le ho lekola kalafo ea kalafo.
Mahlakore a ka moso le liphoso
● Tsoelo-pele ea Mirossal
Patlisiso e tsoelang pele ea tšimo ea minosimal biogy e tsoela pele ho senoloa temoso e ncha ho ts'ebetso le ts'ebetsong ea li-Microsomes tsa sebete. Tsoelo-pele ea Genomong, Maseboomics e ntlafatsa kutloisiso ea rona ea enzisal e kenang hantle le karolo ea bona ea bophelo bo botle le mafu, e le moriana oa hau oa khale.
● Mahlale a hlahang le mekhoa
Mahlale a ntlafalitsoeng le mekhoa ea ho lokisa ho ntlafatsa thuto ea li-Microsomes tsa sebete. Phahameng - Ho Hlaha Scretising, ea Tsoelo-pele ea Khale, Le Lisebelisoa tsa Khale, Le Lisebelisoa tsa Biotechnoloni li sebetsa hantle le mekhoa e mengata ea lithethefatsi.
Mabapi le Iphase
Kantle-hlooho ho la North Wales, Pennsylvania, Iphase Li-Biosciens ke tse ikhethang, lipale, 'me ke bukana ea Iketsang - Phetoho ea Teknoloji ea Reagansosa a koetliso ea likokoana-hloko. Ho ikemisetsa ho etsa lipatlisiso tse batsi le takatso ea lipatlisiso tsa mahlale, sehlopha sa rona sa mahlale se hlahisang bo-rasaense ho fihlela re le bafuputsi ho fihlela ba le bakoeteli ba bona. Ho phehella R & D Hantle ho Bakoahlaho, "Ho Ithuta Bokamoso," Iphase o ile a thehoa linaheng tse fetang 12,000.
Nako ea poso: 2024 - 08 - 09 17:12