Kev Ua Haujlwm ADC los ntawm Cathepsin B hauv DS8201A thiab GGFG - DXD Systems

Lub hauv paus rau phau ntawv

Antibody - Cov tshuaj conjugates (ADCS) tau tawm los ua cov tshuaj tua kab mob ntawm cov tshuaj tua kab mob ntawm cov tshuaj tua kab mob nrog cov tshuaj cytooxic ntawm cytooxic potency. Los ntawm kev siv cov qog - Cov tshuaj tiv thaiv kab mob antibodody, ib qho kev sib txuam nrog cov qog nqaij hlav, thiab muaj kev nyab xeeb dua thiab muaj kev nyab xeeb dua rau cov ntaub so ntswg zoo.

Mechanism ntawm ADCS thiab lub luag haujlwm ntawm Cathepsin B

ADCS tau tsim los xaiv cov khoom xa tuaj cytotoxic rau cov qog nqaij hlav cancer los ntawm kev khi rau cov qog ua rau cov qog. Ib zaug khi, tus ADC yog sab hauv cov recocytosis thiab raug nyiag mus rau lysosome, qhov twg cytotoxic tshuaj yog tso tawm. Ib qho ntawm cov ntsiab lus tseem ceeb koom tes nrog cov kev tso tawm no yog Cathepsin B, ib lub lysosomal cysteine ​​protteine. Cathepsin B plays lub luag haujlwm tseem ceeb hauv cleefide peptide -

DS8201A: Ib qho ntxiv - Ib Tug ADC

DS8201A, tseem hu ua [tshaib-[- - Trastuzumab derxan - Nxki], yog qhia tau zoo tshaj plaws rau kev kho nws tus mob cancer thiab lwm yam HER2 - Kev nthuav qhia cov qog. Nws muaj ib lub trastuzumab - Cov tshuaj tiv thaiv tau txuas rau lub zog todoisomerase i inhibitor payload dhau ntawm ib qho kev sib txuas ntawm tus txiv neej sib txuas. Qhov ADC no muaj cov tshuaj muaj qhov tshuaj tiv thaiv (DAR) piv rau kev nkag mus rau ADCS, coj los txhim kho cov qog nkag mus thiab txhim kho kev tiv thaiv mob cancer. DS8201A kuj tseem ceeb rau nws cov nyhuv los ntawm cov nyiaj tau los, tso cai rau cov paydle los ua diffuse thiab tua cov neeg muaj neeg nyob sib ze tsis hais nws2 qhia.

GGFG - DXD: The Tshiab Linker hauv DS8201a

Lub ntsiab lus tseem ceeb hauv DS8201A txoj kev vam meej yog nws cov cim cleagable linker, ggfg - DXD. Cov peptide no - Raws li Linker muaj cov glycine - phenylalanine - glycine (ggfalan) GGFG Linker yog tsim los txhim kho kev ruaj ntseg hauv kev ncig lub sijhawm thaum ua kom muaj kev tso tshuaj cytoToxic hauv lub qog mis nyuj microenviror.

Tag

ADCS xws li DS8201a sawv cev rau txoj kev hloov pauv ntawm cov kab mob cancer, muab cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj lom neeg nrog cov tshuaj lom neeg lom zem. Lub luag haujlwm ntawm Catepsin B hauv Linker Cleavage, lub tswv yim ggfg - DS8201A suav nrog nthuav tawm cov kev nce qib hauv ADC thev naus laus zis. Raws li ADC kev txhim kho txuas ntxiv mus hloov zuj zus, txuas ntxiv ua kom zoo dua ntawm cov txuas, Payloads, thiab cov tshuaj kho mob uas tau txais txiaj ntsig zoo dua thiab mob qog noj ntshav.

Cov Ntsiab Lus: ADC Linker, PayDload tso tawm, Lysloadal tso tawm, Lysosomal stability, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, lysosome catabolism, Lysosome Catabolism, LS8201A, GGFG - DXD