ADME
Thaum ua cov tshuaj pharmacokinetics, ib qho tseem ceeb ntawm kev soj ntsuam tshuaj preclinical pharmacological, adsorption, tis, metabolism, thiab excretion (ADME) cov khoom yuav tsum tau elucidated thaum lub sij hawm tsim tshuaj. Tshuaj metabolism, los yog biotransformation, yog hais txog cov txheej txheem nyob rau hauv cov tshuaj siv tshuaj raws li kev hloov pauv rau kev nqus thiab tshem tawm hauv lub cev. Muab faib ua theem I & II metabolism, biotransformation feem ntau tshwm sim hauv daim siab, ib qho khoom nruab nrog cov enzymes metabolic, thiab tseem nyob rau hauv lwm yam kabmob xws li hnyuv, raum, ntsws, ntshav, thiab tawv nqaij.
Ib qho tseem ceeb, qhov teeb meem nyuaj hais txog cov tshuaj metabolism hauv cov tshuaj yog kev nthuav tawm ntawm kev tshawb pom los tsim kev sib raug zoo rau kev kwv yees cov tshuaj metabolic hauv tib neeg, kev siv tshuaj zoo thiab kev nyab xeeb. Ob peb xyoos dhau los, IPHASE tau tsim ntau yam khoom siv rau cov tshuaj metabolism hauv kev tshawb fawb nrog rau cov metabolic stability, metabolic phenotype, enzyme inhibition (IC).50). Tsis tas li ntawd, IPHASE tseem muab cov qauv zoo hauv cov qauv hauv vitro xws li thawj hepatocytes, daim siab thiab plab hnyuv microsomes, S9 feem, cytosol, CYP recombinases sau los ntawm cov hom tshwj xeeb ntawm ntau lub xeev.