Taw qhia rauThawj Hepatocytes
Cov Hepatocytes yog lub pob kws ntawm daim siab tshawb fawb thiab muaj qhov tseem ceeb hauv kev nkag siab lub siab ua haujlwm, thiab kab mob siab. Raws li lub xov tooj ntawm tes tau pom hauv daim siab, Hepatocytes muaj kwv yees li 70 - 80% ntawm daim siab cytoplasmic loj. Lawv ua tub rog tseem ceeb hauv cov txheej txheem metabolic, detoxification, thiab protein synthesis. Tsab ntawv no rho tawm rau hauv lub ntiaj teb intricate ntawm thawj hepatocytes, tshawb txog lawv qhov tseem ceeb, kev siv, thiab cov kev thov yav tom ntej, thiab cov kev thov yav tom ntej.Kev rho tawm thiab kev coj noj coj ua ntawm hepatocytes
● Cov tswv yim rau kev rho nyiaj lus Askiv
Cov Hepatocytes yog cais tawm ntawm daim siab nqaij daim tawv los ntawm cov txheej txheem me heev uas ua kom muaj siab dua tshiab hepatocytes rau kev tshawb fawb. Tus txheej txheem no feem ntau yuav cuam tshuam nrog kev nplua ntawm daim siab nrog cov kab mob siab los ntawm cov txheej txheem filtation thiab cov txheej txheem centrifugation kom huv sipatocytes. Qhov zoo tshaj ntawm Hepatocytes tau txais yog qhov tseem ceeb, raws li nws tau txiav txim siab lawv cov nqi hluav taws xob hauv kev tshawb fawb thiab chaw kuaj mob.● Cov kev sib tw hauv Hepatocyte kab lis kev cai
Posturing thawj hepatocytes twv cov nyom sib tw, feem ntau vim yog lawv lub neej tsawg thiab muaj zog kom poob daim siab - lub sijhawm tshwj xeeb. Tswj siab rau siab - Kev ua tau zoo thawj Hepatocytes hauv Vitro yuav tsum muaj ib puag ncig kev coj noj coj ua uas tsis muaj mob physiological. Kev nce qib hauv cov txheej txheem kev coj noj coj ua, suav nrog cov tshuab kab lis kev cai thiab peb - Scaffolds, raug tsim los ua kom kov yeej cov kev txwv.Lub luag haujlwm ntawm Hepatocytes hauv lub siab
● Cov haujlwm ua haujlwm ntawm hepatocytes
Thawj Hepatocytes yog cov metabolic fais fab ntawm daim siab, lub luag haujlwm rau ib cov txheej txheem tseem ceeb, suav nrog gluuconogenesis, glycogen cia, thiab lipid metabolism. Lawv ua lub luag haujlwm tseem ceeb hauv kev tswj cov piam thaj hauv cov hav zoov, ua rau lawv lub hauv paus hauv kev kawm hauv kev kawm txog kev ua ntshav qab zib xws li ntshav qab zib thiab rog.Prot Cov txheej txheem Detoxifications
Hepatocytes yog qhov tseem ceeb rau kev ua haujlwm ntawm cov tshuaj lom endogenous thiab exogenous tshuaj, suav nrog cov tshuaj thiab co co. Los ntawm theem I thiab theem II methok metions, pab txhawb nqa los ntawm cov suite ntawm cov enzymes xws li Cytochrome P450S, Hepatocytes Hloov thiab siv cov khoom sib txuas ntxiv - soluble rau excretion. Nkag siab cov txheej txheem no yog qhov tseem ceeb rau kev tsim tshuaj thiab ntsuas tus Hepatotoxicity ntawm cov teb tshiab.Cov ntawv thov hauv kev tshawb tshuaj tshuaj thiab kuaj
● Hepatocytes hauv Pharmacokinetics
Hauv kev pom cov tshuaj, thawj Hepatocytes yog qhov muaj txiaj ntsig rau kev kawm cov tshuaj hauv tsev kws tshuaj muaj kev txhawj xeeb nrog kev txav ntawm cov tshuaj nyob hauv lub cev. Lawv tau siv los ntsuas kev nqus, faib, cov metabolism, thiab ua rau cov neeg sib tw ntawm cov neeg sib tw tshiab. Raws li ib tug thawj coj Greepatocytes cov chaw muag khoom, cov tuam txhab siv zog los muab cov hepatocytes uas pab txhawb kev paub tseeb thiab txhim khu kev qha ntawv pom zoo.● Kev tshawb fawb toxicology siv Hepatocytes
Thawj Hepatocytes ua lub luag haujlwm tseem ceeb hauv Kev Kawm Txog Kev Kawm Toxicology, ua rau cov kws tshawb fawb los ntsuas tus Hepatotoxicity ntawm cov tshuaj tshiab thiab tshuaj lom neeg. Qhov muaj ntawm siab - Cov Hepatocytes tseem ceeb hauv kev tshawb fawb no, raws li lawv tso cai rau kev ntsuam xyuas ntawm lub peev xwm kho tau zoo.Hepatocytes nyob rau hauv regenerative tshuaj
● Siv hauv daim siab kho mob kho
Lub peev xwm ntawm GEPATOCYTES hauv cov tshuaj uas muaj txiaj ntsig yog qhov tseem ceeb, tshwj xeeb yog nyob rau hauv cov ntsiab lus ntawm daim tawv hloov pauv thiab daim siab kev hloov pauv. Kev tshawb fawb yog tsom rau kev siv Hepatocytes los txhim kho cov cuab yeej siab thiab kev kho mob cell uas tuaj yeem hloov lossis txhawb nqa daim siab ua haujlwm.● Kev kho siab nyob rau hauv daim siab muab tshuaj engineering
Daim ntaub so ntswg ua kom pom cov hom phiaj ua haujlwm los tsim cov haujlwm ua haujlwm ntawm daim tawv nqaij los ntawm thawj hepatocytes. Kev nce qib hauv daim teb no, xws li kev txhim kho biocomple scaffolds thiab peb - Kev cog lus rau kev tsim daim ntawv kho mob thiab muab lwm txoj kev kho mob rau daim siab hloov ntshav.Molecular txheej txheem hauv Hepatocytes
Stiduct Transduction txoj kev
Thawj Hepatocytes tau koom nrog intricate teeb liab kev hloov pauv txoj kev uas tswj daim siab muaj nuj nqi, suav nrog cov metabolism thiab cov kua txiv qaub. Nkag siab txog cov kev pom zoo no rau hauv daim siab pheeb suab pheeb suab pheeb suab pheeb suab rau kev txhim kho cov hom phiaj tshiab rau cov mob siab.● Cov Thawj Coj Qhia Cov Cai
Cov kev cai ntawm cov gene qhia hauv hepatocytes yog qhov tseem ceeb rau kev tswj daim siab - cov haujlwm tshwj xeeb. Cov tswv yim xws li RNNle ExtraCress thiab Crepre Editing tab tom ua haujlwm los kawm cov qauv kev hais lus Gene cov kab mob thiab tshuaj yeeb.Qhov sib txawv ntawm cov thawj thiab lwm tus hepatocytes
● Lub xub ntiag zoo ib yam tsis muaj kev lom zem
Cov Hepatocytes yog qhov txawv ntawm kev tsis txawj ua Hepatocyte xovtooj ntawm tes feem ntau los ntawm lawv txoj kev pheeb suab pheeb suab. Thaum lub sij hawm immortalalized xovtooj ntawm tes muab kev yooj yim thiab txuas ntxiv lub neej, lawv feem ntau tsis muaj qhov tshwj xeeb hepatocytes qhov kev xaiv tshwj xeeb rau ntau qhov kev siv.● Hauv vivo vs. hauv cov vitro sib txawv
Hauv cov kev tshawb fawb vitro siv cov Hepatocytes yuav tsum muaj npe rau qhov sib txawv ntawm Vivo thiab hauv cov kev mob vitro. Cov kev sib txawv no tuaj yeem cuam tshuam rau cov extrapolation ntawm kev sim nrhiav kev txawj ntse los yog pathological cov kev kawm uas zoo dua mimic hauv vivo daim siab ua kom ib puag ncig.Thawj Hepatocytes nyob rau hauv tus qauv kab mob
Liaj Ua Qauv Mob Siab
Thawj Hepatocytes yog qhov tseem ceeb hauv kev ua qauv rau daim siab mob, suav nrog kab mob siab, mob qog noj ntshav. Los ntawm kev ua kom muaj kab mob kab mob hauv vitro, cov kws tshawb nrhiav tuaj yeem kawm cov kab mob kev kawm, nce qib peb txoj kev nkag siab ntawm daim siab pathologies.● Nkag siab Hepatocyte - Cov Pathologies
Hepatocyte Tysfunction yog nyob ntawm qhov tseem ceeb ntawm ntau daim siab kab mob. Kawm Qeb Thawj Hepatocytes muab kev nkag siab rau hauv cov txheej txheem rau kev txhim kho cov kab mob no, yooj yim cov tswv yim ntawm cov tswv yim.Cov kev sib tw thiab cov kev txwv nyob rau hauv Kev Tshawb Fawb Hepatocytete
● Kev muaj peev xwm thiab kev ua haujlwm teeb meem
Thawj qhov kev sib tw hauv Hepatocyte kev tshawb fawb yog kev tswj hwm kev muaj mob cell thiab ua haujlwm nyob rau lub sijhawm. Qhov kev txwv tsis pub muaj peev xwm ntawm cov hepatocytes yuav tsum tau siv thiab tawm tswv yim kom txuas ntxiv lawv lub neej thiab khaws cia lawv ua haujlwm.Kev txwv nyob rau hauv ntev - Lub Sij Hawm Kev Lag Luam
Ntev - Lub sij hawm kab lis kev cai ntawm cov hepatocytes tseem ceeb heev, raws li hepatocytes yuav plam lawv lub siab - cov yam ntxwv tshwj xeeb dhau sijhawm. Kev tshawb fawb txuas ntxiv tau tsom mus rau kev tsim cov kab lis kev cai txhawb nqa ntev ntev - Lub sij hawm tsis yog - Parenchymal nplooj siab thiab kev siv ntawm bioengineered extractium matrices.Yav Tom Ntej Cov Lus Qhia hauv Hepatocyte Kev Tshawb Fawb
Kev Tsim Kho Hauv Kev Tshaj Tawm Hauv Hepatocyte Technologies
Daim teb ntawm Hepatocyte kev tshawb fawb yog sai heev nrawm nrawm dua zuj zus thiab kev nce qib thev naus laus zis rau kev coj noj coj ua cell thiab tsom xam. Orgoid thev naus laus zis, microfluidic cuab yeej, thiab siab - Los ntawm kev nrhav cov kev ua tau rau thawj cov ntawv thov Hepatocyte.Tej Peev Xwm Kev Siv Tshuaj Tus Kheej Tshuaj
Thawj Hepatocytes tuav cov lus cog tseg rau cov tshuaj kho tus kheej, tshwj xeeb hauv cov neeg mob tu cov neeg mob raws li lawv cov cim lub siab metabolism. Lub neej tom ntej ntawm Hepatocyte kev tshawb fawb cov lus dag hauv kev sib xyaw genomic, thiab cov ntaub ntawv metabolic kom ua tiav cov tswv yim kho tus kheej rau cov kab mob siab thiab dhau mus.Xaus: Qhov tseem ceeb ntawm kev them nqi Hepatocytes thiab Tuam Txhab Taw qhia
Thawj Hepatocytes nyob twj ywm hauv cov cuab yeej tseem ceeb hauv cov realms ntawm biomedical kev tshawb fawb, tshuaj nrhiav pom, thiab muaj cov tshuaj kho mob. Kev sib tw txuas ntxiv thiab kev tshawb fawb nyob rau hauv Hepatocyte kev tshawb fawb tau hais txog qhov tseem ceeb ntawm cov hlwb no nyob rau hauv unraving complex ua haujlwm thiab vam khom tib neeg kev noj qab haus huv.Lub tsev nyob hauv North Wales, Pennsylvania,AtheBiosciences yog ib qho tshwj xeeb, tshiab, thiab kev tsim kho siab tshiab ua haujlwm, kev tsim khoom, kev lag luam ntawm cov tshuaj tiv thaiv roj ntsha tshiab. Nrog cov kev paub dav dav thiab ib qho kev mob siab rau kev tshawb fawb txog kev tshawb fawb thoob ntiaj teb, kev pab tshawb fawb hauv kev ua tiav lawv cov hom phiaj dav dav ntawm ntau dua 2,000 tus kheej - Tsim cov khoom lag luam.
Lub Sijhawm Post: 2024 - 12 - 09 10:22:21:21