Lub tsev Ntxias IPhase tib neeg cy3a4 + reductase

IPhase tib neeg cy3a4 + reductase

Cov lus piav qhia luv luv:

Cov CYP450 tau rov qab los ntawm cov caj ces engineering ntawm cy450 gene thiab qhia tawm hauv E. coli lossis kab cells. Tus Kheej Cy450 Islozyme yog qhia thiab ua kom huv, thiab siv cov meticolism, yeeb tshuaj polymorphism thiab yeeb tshuaj sib txuas lus. Cov tsiaj sib txawv ntawm cov tshuaj metabolism tuaj yeem muab tso tawm los ntawm kev sib piv metabolites ntawm cov neeg sib tw tshuaj uas mob siab cy450 enzymes.

Hu rau tam sim no Ntxiv rau lub tawb nqa khoom

Khoom Qhia Qhia

Khoom Ntawv

Cov Khoom Nrhabrraption discription

N / a

Qeb:
Txoj kev
Yam khoom tsis tau.:
0161A1.09
Chav Tsev Loj:
0.5ml, 0.5nmol
Cov ntaub so ntswg:
N / a
Hom:
Tus neeg
Sib deev:
N / a
Kev Cia Cov Neeg Cia thiab Tsheb Thauj Mus Los:
Khw ntawm - 70 ° C. Dej khov kom qhuav.
Kuaj System:
Recombant cyp450 enzymes
Cov tau txais daim ntawv thov:
Hauv VeneRo Tshuaj Tshuaj Yeeb Yam

Yav dhau los: Iaphas tib neeg cy3A4 + Reductase + B5

Tom ntej: IPhase tib neeg cyp2e1 + reductase

IPhase tib neeg cy3a4 + reductase

Cov lus piav qhia luv luv:

Khoom Qhia Qhia

Khoom Ntawv

IPhase luav (New Zealand dawb) PBMC, tshiab

Iphas ib txwm tib neeg hepatic kupffer hlwb

Iphas dev (Beagle) ntshav, ib tus neeg pub dawb, poj niam, h cuag cov sodium

Iphase nas (ICRN / ACD - 1) Ntshav, sib xyaw tub los ntxhais, h cuag tub los ntxhais, hindarin sodium

Iphase liab (cynomolgus) cov ntaub so ntswg quav, txiv neej

Iphase liab (cynomolgus) ntsws microsomes