Lub hauv paus rau phau ntawv
T cells yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob, ua lub luag haujlwm tseem ceeb hauv kev txheeb xyuas thiab kev sib txuas ntawm cov pathogens. Cov txheej txheem ntawm t cell kev ua kom yog qhov nyuaj, ntau - kev siv mechanism uas cuam tshuam cov kev sib cuam tshuam ntawm kev sib cuam tshuam ntawm kev sib cuam tshuam ntawm kev sib txuam ntawm kev mob hlwb thiab cov cim qhia biochemical. Nkag siab txog cov txheej txheem no yog qhov tseem ceeb rau nce qib kev txhaj tshuaj thiab kev txhim kho kev kho mob zoo xws li mob qog noj ntshav thiab autoimmune tsis zoo. Hauv tsab xov xwm no, peb yuav tshawb txog ntau theem ntawm T Cell kev ua kom muaj kev ua kom muaj clonal nthuav dav thiab kev cai, thaum tseem yuav ua kom nce qib tshiab hauvt cell urteration khoom sivs.
Antigen kev nthuav qhia thiab paub
Wotle Lub luag haujlwm ntawm Antigen - Kev nthuav qhia cov hlwb (APCS)
Antigen - Kev nthuav qhia cov Hlwb (APCS) yog qhov tseem ceeb hauv kev pib ntawm T Cell kev ua kom tiav. Cov hlwb tshwj xeeb no, uas suav nrog cov hlwb dendritic, macrophages, thiab B hlwb, ntes rau ntawm pathogens thiab qhia lawv ntawm lawv lub npoo rau t hlwb. Qhov kev nthuav qhia no tshwm sim los ntawm cov qauv tseem ceeb atherocompatibilibility ntau (MHC) lwg me me, uas yog qhov tseem ceeb rau kev lees paub ntawm antigens los ntawm t hlwb.
● Cov kev ua yeeb yam tseem ceeb atherocompatibility (MHC) kev sib cuam tshuam
Qhov kev sib cuam tshuam ntawm MHC lwg me me ntawm APCS thiab T Cell Receptors (TCRS) ntawm T Cell yog lub pob zeb ua kom lub tsev. MHC chav kawm kuv lwg tam sim no endogenous endigens rau cd8 + cytotoxic t hlwb, thaum MHC Class II molecules tam sim no exigens rau CD4 + Helper T cell. Qhov kev cuam tshuam tshwj xeeb no kom ntseeg tau tias t cell tuaj yeem txheeb xyuas qhov tseeb thiab teb rau ntau cov pathogens.
Cell RECeptor (TCR) Kev Sib Koom Tes
● Cov qauv thiab kev ua haujlwm ntawm TCR
Lub cell receptor (tcr) yog cov qauv muaj protein ntau nyob rau saum npoo ntawm t hlwb. Muaj cov alpha thiab beta chains, tcr pom tau thiab khi rau cov antigens hais los ntawm MHC lwg me me. Qhov hloov siab hauv tus qauv TCR.
● Muaj feem ntau ntawm kev paub txog kev paub
Qhov tshwj xeeb ntawm tcrs yog txiav txim siab los ntawm kev tshwj xeeb ntawm amino acids nyob rau hauv cov kab sib txawv ntawm alpha thiab beta chains. Qhov tshwj xeeb no yog qhov tseem ceeb rau kev ua kom muaj zog ntawm lub zog tiv thaiv kev tiv thaiv kev tiv thaiv kab mob c cors tau paub qhov txawv ntawm tus kheej thiab tsis yog - tus kheej awigens. Siab - Zoo T Cell Muab cov khoom siv yog tsim los ua kom muaj tseeb no thaum cov txheej txheem sim, muab cov txiaj ntsig txhim khu kev qha thiab txhim khu kev txhim khu kev qha.
CO - Kev Taw Qhia Cov Teeb Meem
● Qhov tseem ceeb ntawm cov cim theem nrab
T Cell Kev Ua haujlwm tsis yog ib leeg nyob ntawm kev paub txog kev paub; Nws tseem yuav tsum tau cov cim theem nrab, CO - kev txhawb nqa cov paib kom mus. Cov phiajcim no tsim nyog rau kev qhib t hlwb thiab tiv thaiv tsis taus (tsis ua haujlwm). Qhov qhaj ntawv ntawm CO - cov phiajcim cov paib yuav ua rau muaj kev tiv thaiv kev tiv thaiv kev tiv thaiv, uas yog qhov tseem ceeb rau kev tiv thaiv autoingpune kab mob.
● Cov qauv tseem ceeb
CO - stimulatoratory alolecules xws li CD28 nyob rau ntawm Cells thiab B7 ntawm APIVOTAL lub luag haujlwm hauv kev muab cov cim tsim nyog rau kev ua haujlwm cell. Kev sib cuam tshuam ntawm CD28 thiab B7 txhim kho T Cell muaj kev vam meej, ciaj sia, thiab cytokine ntau lawm. Lwm co - stimulatoratory alolecules, suav nrog ocos thiab ox40, ntxiv kev coj ua kom ua kom thiab sib txawv ntawm t hlwb. T cell ua kom cov khoom siv tau tsim los ntawm cov chaw muab cov khoom siv tseem ceeb los pab txhawb kev ua kom muaj zog thiab siv tau cell ua haujlwm.
Daim phiaj kev hloov chaw pathways
● Lub phiajcim untracellism
Thaum lub tcr thiab co - stalulatoratory molecules tau koom nrog lawv txoj kev ua si ligands, ib qho teeb meem ntawm cov phiaj xwm nkag mus. Cov phiajcim kev taw qhia sib xyaw ua ke cov txheej txheem no thiab kev ua kom muaj ntau yam Kinases, xws li LCK thiab ZAP - 70. Cov kab ke no phosphorylate hauv cov protein adeins, ua rau muaj kev ua kom muaj ntau txoj kev teeb tsa pathways, suav nrog Mapk, NF - κB, thiab NFAT txoj hauv kev.
● Cov protein tseem ceeb thiab enzymes koom nrog
Proteins xws li Lam Lam (Linker rau kev ua kom t hlwb) thiab sra) 76 (shi dicifying protein ntawm 76 (kev teeb tsa lub cim uas xav tau rau t cell ua kom tau. Enzymes zoo li phospholhipase c - γ - γ - γ - γ - γ) Ua si ib lub luag haujlwm tseem ceeb hauv kev xa cov cim thib ob uas txuas ntxiv ua kom cov paib kom ua kom muaj zog. Siab - Cov Khoom Zoo T Cellource cov khoom siv feem ntau siv cov ntsiab lus protein tseem ceeb no thiab cov enzymes kom ntseeg tau tias muaj teeb meem teeb meem zoo hauv kev sim.
Cytokine ntau lawm thiab teb
Cov Cytokines tsim tawm
Ua kom t hlwb ua ntau cytokines uas ua rau lub cev tiv thaiv kab mob. Cytokines suav nrog cov kev sib txuas lus sib xyaw (IL Txhua cytokine muaj cov haujlwm tshwj xeeb, xws li kev txhawb nqa t cell proliferation, txhim kho cytotoxic kev ua si, thiab tswj kev o.
Lub luag haujlwm hauv T Cell txawv thiab muaj kev cuam tshuam
Cytokines ua si lub luag haujlwm tseem ceeb hauv kev txiav txim siab txoj hmoo ntawm kev qhib t hlwb. Piv txwv li, IL - 2 yog qhov tseem ceeb rau kev nthuav dav clonal ntawm t hlwb, thaum il - 12 txhawb nqa qhov sib txawv ntawm naïve t hlwb rau hauv th1 hlwb. Lub xub ntiag ntawm cytokines tshwj xeeb sau cia cov cell yuav dhau los ua tus pab cell, ib cytotoxic t cell, lossis ib txoj cai t cell. T cell ua kom cov khoom siv los ntawm cov npe nrov tsim tawm los ua kom raug cytokine ntau lawm, cov kev kawm kom yooj yim ntawm T Cell muaj nuj nqi thiab sib txawv.
T CELL COB
Tsim kev sib txawv ntawm t cell pab
Kev ua raws li nram qab no, t cells sib txawv rau hauv ntau cov kev ua haujlwm, txhua tus nrog cov haujlwm sib txawv. CD4 + HOLPER T cell tuaj yeem sib txawv mus rau TH1, th17, thiab cov kev cai tswj t hlwb (tregs), txhua subset ua si rau kev tiv thaiv. Th1 cov hlwb muaj feem cuam tshuam hauv cell - Kev sib xyaw ua ke, th2 hlwb hauv kev tiv thaiv kev tiv thaiv, th17 hlwb hauv kev tiv thaiv kab mob.
● Kev ua haujlwm ntawm txhua tus subset
Lub luag haujlwm tshwj xeeb ntawm t cell kev ua kom ua rau lub cev tsis muaj zog tiv thaiv kev tiv thaiv kab mob sib txawv. Th1 cov hlwb ua cov IFN - γ thiab yog qhov tseem ceeb rau kev sib txuas ntawm cov kab mob intracellidular zoo li cov kab mob thiab qee cov kab mob. Th2 hlwb ua IL - 4, IL 200 5, thiab IL 2014 13, uas yog qhov tseem ceeb heev rau kev ntaus cov roj hmab ntxiv. TH17 hlwb zais cia il - 17 thiab yog koom nrog hauv kev mob mob thiab mob autoimmune autoimmune. Kev cai lij choj t hlwb ua rau il - 10 thiab tgf - β, tswj kev tiv thaiv kev tiv thaiv etostasis thiab tiv thaiv autoimmunity. Kev tsim kho lub xov tooj ntawm tes ua kom cov khoom siv ua kom yooj yim hauv cov vitro sib txawv thiab kev tshuaj xyuas cov kev tshawb xyuas no, kev tshawb nrhiav hauv kev txhaj tshuaj thiab kev kho kom zoo.
Clonal Expansion thiab Nco Tsim Tsim
● Qhov kev nthuav dav ntawm kev ua haujlwm t hlwb
Thaum tau txais cov cim ua kom muaj zog thiab cytokine stimulation, qhib t hlwb yauv mus nrawm. Tus txheej txheem no, hu ua Clonal nthuav dav, tshwm sim nyob rau hauv ib tug pejxeem loj ntawm effector t cells uas tuaj yeem teb tau zoo rau cov antigen. Qhov proliferation yog tsav los ntawm cytokines xws li iL - 2, uas cov cim los ntawm cov IL - 2 tus receptor los txhawb nqa cov voj voog ntawm tes thiab kev muaj sia nyob.
Kev txhim kho ntawm lub cim xeeb T hlwb
Lub cim ntawm cov txheej txheem tiv thaiv kab mob yog qhov tsim ntawm lub cim xeeb c cells, uas tau muab kev tiv thaiv ntev. Tom qab qhov kev tshem tawm ntawm cov pathogen, qee qhov qhib t hlwb sib txawv rau hauv lub cim npe T cell. Cov hlwb no tsis tu ncua hauv lub cev thiab tuaj yeem mount cov lus teb nrawm thiab muaj zog nyob ruaj raws li re - raug rau tib tus antigen. Cov khoom ua tau zoo ntawm cov khoom siv cell ua kom cov khoom siv yog instrumental hauv kev kawm cov txheej txheem kev kawm txog lub cim xeeb T cell kev tsim thiab txij nkawm.
Cov kev cai ntawm t cell ua kom tiav
● Cov tshuab ntawm cov kev cai lij choj tshuaj xyuas
T Cell Kev ua kom nruj nreem los ntawm cov neeg kuaj xyuas tsis muaj zog los tiv thaiv kev tiv thaiv tsis muaj zog ntau thiab cov lus teb pib. Kev tiv thaiv kab mob tsis muaj zog yog qhov chaw tsis muaj kab mob uas ua rau lub cev tsis muaj zog. Qhov tseem ceeb tiv thaiv kab mob muaj xws li CTla - 4 (CyTotoxic t - Lymphocyte - 1 (uas tsis zoo cov protein 1), uas tsis zoo xaiv T cell kev ua kom tiav thiab ua haujlwm.
Wrole Lub luag haujlwm ntawm kev ua yeeb yam ntawm cov cim (CTLA - 4, PD - 1, thiab lwm yam)
CTLA - 4 kev sib tw nrog CD28 rau kev khi rau B7 molecules ntawm Apcs, xa cov cim hauv Aibitege cov paib uas dampen t cell urpication. Pd - 1, raws li kev khi rau nws liigands PD - L1 thiab PD - L2, inhibits t cell receptoring thiab txo cytokine ntau lawm. Cov teeb liab inhibitory kos npe yog qhov tseem ceeb rau kev tswj hwm kev tiv thaiv kev tiv thaiv thiab tiv thaiv autoimmunity. T cell ua kom cov khoom siv ua ke los ntawmAtheBiosciences sib xyaw ua ke los kawm cov kev tswj hwm cov kev tswj hwm cov kev tswj hwm cov kev tswj hwm hauv kev tiv thaiv kev tiv thaiv kev tiv thaiv kev tiv thaiv kab mob thiab cov peev xwm kho tau.
Cov chaw kuaj mob cuam tshuam thiab siv cov ntawv thov kho mob
● Kev siv rau kev autoimmunity thiab mob cancer
Aberrance nyob rau hauv t cell ua kom muaj zog tuaj yeem ua rau autoimmune kab mob, qhov twg tus kheej - reactive t cells tua cov ntaub so ntswg. Conversely, tsis txaus T Cell ua kom muaj zog tuaj yeem ua rau muaj kev tiv thaiv kev tiv thaiv, tso cai rau cov kab mob thiab mob qog noj ntshav rau cov khoom siv. Nkag siab txog cov intricacies ntawm cell kev ua kom muaj kev cuam tshuam muaj txiaj ntsig zoo, muab cov kev kho mob rau kev txhim kho kev kho mob los kho cov lus teb tsis sib haum.
● Kho cov tswv yim rau cov tswv yim t cell ua kom tiav
Kho cov tswv yim hom phiaj rau kev ua haujlwm cell suav nrog kev txhaj tshuaj tiv thaiv kab tiv thaiv kev tiv thaiv kab mob, uas thaiv cov cim rau cov qog. Tsheb - T Cell Kev Kho Mob Corolves Cornves T Cell los qhia txog Chunteric Antigen cov khoom txais uas cov tshuaj mob cancer. Cov kev kho mob no tau pom zoo nyob hauv kev kho qee lub cancer. Ib qho ntxiv, cov tswv yim los ua kom lub cev tiv thaiv kab mob tiv thaiv tau raug tshawb xyuas rau cov kab mob autoimmune. Siab - Cov khoom zoo t cell ua kom cov khoom siv los ntawm cov ua lag luam yog cov cuab yeej tseem ceeb hauv kev txhim kho thiab kev ntsuas cov kev kho mob tshiab.
Txog Iphase Biosciences
Lub tsev nyob hauv North Wales, Pennsylvania, Ipase Biosciences yog qhov tshwj xeeb, thiab kev pabcuam siab tshiab, thiab kev pabcuam roj ntsha tshiab. Kev paub ntau yam thiab kev nyiam ua rau kev tshawb fawb, peb pab kws tshawb fawb thoob plaws hauv lawv cov hom phiaj kev kawm thoob plaws hauv lawv cov hom phiaj kev tshawb fawb. Kev nrhiav tus R & D Qhov zoo tshaj plaws ntawm "kev tsim tawm tshiab, tshawb nrhiav yav tom ntej, cov chaw muag khoom, thiab cov chaw muag khoom Asmeskas, thiab cov chaw muag khoom East
Lub sij hawm Post: 2024 - 09 - 25:40:30