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Since the drug metabolizing enzyme activities gradually decrease with the prolongation of in vitro incubation time, traditional in vitro metabolism models have limitations such as short incubation tim
Micronuclei are whole chromatids or acentric fragments or ring chromosomes which remain in the cytoplasm when chromosomes regularly enter daughter cells to form nuclei after mitosis.
PDC in vitro ADME research model PDC takes into account the characteristics of both large and small molecules. Therefore, in vitro ADME research on it needs to take into account homing peptides, linke
The isolation of Peripheral Blood Mononuclear Cells (PBMC) is a crucial technique in biomedical research and clinical applications. These cells include lymphocytes (e.g., T cells, B cells, NK cells) a
The 63rd SOT ended perfectly, and the excitement of IPHASE-US never ends!
The 63rd Annual Meeting and Exposition of the American Society of Toxicology was successfully held from March 10-14, 2024, in
The in vivo alkaline comet assay has been increasingly used in the genotoxicity evaluation of compounds. ICH S2(R1) has included the liver comet assay as the 2nd in vivo test for tissues/endpoints; an
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