Lysosomes (Tritosomes): Kufungidzira muVitro Test System yeCatabolism kana Lysosomal Stabilation Zvidzidzo

Zvigadzirwa zvePhase

NhanganyayaLysosomes
Rangarirai rondedzero yakawanikwa neChristian Didhani muma1950s uye vakasimbiswa seiyo organelle yeshongwe uye metabolism muchitokisi. Lysosoms haana kuroora - Membrane, Dynamic, Heterogenous organelles inosiyana munzvimbo, morphology, saizi, enzyme zvirimo, uye subyme. Iyo lysosomal membrane ine mazana emazana ePeripheral membrane mapuroteni, kusanganisira akasiyana-siyanavatengesiuye neIon nzira. Iyo Lysosomal Mults - Subunit v - Atpase inochengetedza iyo acidic lysosomal lumen. Iyi yakaderera Ph) Lysosomes anogashira uye kugaya madiki mamorekuru uye itsocytosed zvinhu, itsoculf zvigadziko zvemukati zveCytoplasmia Naizvozvo, manosomes akawana nguva yakareba akaonekwa se "kudzokorora bhini" yechitokisi.

Triposome

Tritosomes inonyatso subcellular zvivakwa zvakabatanidzwa mune dzakasiyana siyana cellular maitiro, kunyanya mumutemo we metabolic nzira uye kuchengetwa kwemasero emota. Tritosomes anowanzodzidziswa mumamiriro ezvinhu ebasa ravo mukati medzidzo yezvinhu. Iyo yekutsanangura chikamu chezvigadzirwa izvi ndezvazvo zvakasarudzika, izvo zvinovatendera kuita mabasa akaomesesa izvo zvinokoshesesa nekuita masero echokwadi. Rat livert tritosomes iri Hepatic Rysosomes Izvo zvakatemerwa neTyloxapol (Triton dri 1339), A Isiri - ionic siractorctant. Lysosomes ane tylosapol kuratidzira kudzikiswa kwakadzikira, kunogona kuve kwakawedzera kusarudzika kubva kuMitochondria, uye kusvibisa majekiseni anowira pasi neyechisikigo densosomal densities.

Kushandiswa kweRysosomes
· Diki Nucleic acid zvinodhaka uye mansosomes
Diki Nucle acid Zvinodhaka zvinoreva zvidimbu zvidiki zveNucleotides neChicleides neChicleides iyo inogona kusunga mrnas yakananga uye inokanganisa kushanda kweiyo mnnas yekuwedzera kuzadzisa maitiro ekupedzisira. Diki Nucle acid Zvinodhaka zvinosanganisira AntiseNucle Oligonucleideides (Asos), Sirner (Sirna), Rna Aptamers, Aso naSirna ndiro

Mushure mekutonga, madiki madiki acid zvinodhaka anotanga kudzivisa kusvibiswa nemapundu. Lysosomes inogona kushandiswa seyakaongororwa bvunzo yekuongorora shanduko yekugadziriswa kwechiyero chechiitiko cheLysosoms muVitro

· A · ANTIVERISE - CONG CONJUGATA (ADC) uye mansosomes
Antibody - Zvinodhaka Conjugate (Adc) rudzi rutsva rwebhotiya rinodhaka iyo vakaroorana madiki mamorekuru kuti vataridzwe antibodies kana antibody zvidimbu kuburikidza nehutachiona. Zvinogona kusimudzira kunakidza kwezvinodhaka uye kugadzikana, kuderedza kiriniki nechero uye mhedzisiro, uye kugadzirisa iyo yekurapa index. Iyo ine zvese zvinouraya mhedzisiro yemishonga madiki madhiragi mishonga uye chinangwa chemishonga inodhaka. Iyo inonyanya kushandiswa mukurapa kurapwa kweanti - bundu kana zvimwe zvirwere.

Mushure mekupinda mumuviri, maADC mamorekuru anogona kusunga kune zvimedu zvemukati zvemasero ekutungamira kuburikidza nekutungamirirwa kweMonoclonal antibodies, uye kumwe kuenderera mberi mumasero emanyowa. Iyo Adc mamorekuru inopinda mumasero (kunyanya muRysosomes) inogona kusunungura madiki molyuble toxins (i.e. ADC inoda Inoshanda Lysosomes kuti igadzirise uye kusunungura mishonga madiki anoshanda nesimba ravo, kupinda muRysosomal meysosomes, uye kuwirirana nemanyorerwe emanyorerwo ari muCytoplasm kana Nucleus. MuVitro kuyedza kweADC uye Lysosomes vanogona kuongorora kuti ruzha runogona kupiwa nemishonga yezvidiki zvekusunungura, kupa muVitro Ongorora chishandiso chekugadzira yeADC Land Linc Linc Linc Linc Linc Linc Linc Linc Linc Linc Linc Lincal.

About Pipase
Semutengesi anotungamira weVitro Biological Reagents, Ifavera akatanga kurovedzwa kweropa.
· Huke enzyme chiitiko: Iphase chiropa chiLysosomes zvakaedzwa kuitira Cathepsin b uye acid phonzatase chiitiko, uye chiitiko che enzyme chiri kufanana kana chakakwira pane zvigadzirwa zvakafanana kunze kwenyika.
· Batch kugadzirwa: Batch kugadzirwa kunotorwa, uye iyo hesimba rakakwanira kuve nechokwadi chekuwanikwa kweiyo imwe batch yezvigadzirwa.
· Bvisa Yekutumira Nguva: Yakazvimirira Kutsvaga uye Kubudirira, akawanda Warhouses mu Stock, kuve nechokwadi chekushandisa vatengi.