Lehae ADME IPHASE Phase II Metabolic Stability Kit,Beagle

IPHASE Phase II Metabolic Stability Kit,Beagle

Tlhaloso e Khutšoanyane:

Phase II metabolism, eo hape e tsejoang e le karabelo e tlamang, e bua ka karabelo eo mohato oa I metabolites kapa lithethefatsi tsa prototype li kopanang le limolek'hule tse nyane tse sa feleng ka li-enzyme tsa mohato oa II, tse lebisang phokotsong ea chefo, ts'ebetso, kapa polarity ea lihlahisoa. Karolong ea II ea metabolism, karabelo e atileng haholo ke glucuronidation, eo ka nako eo uridine diphosphate glucuronic acid (UDPGA) e tlangoang ho prodrug ka catalyzation ka glucuronyl transferase ho li-microsomes. The glucuronide e eketsa ho qhibiliha ha metsi ho metabolites ho ntlafatsa mokelikeli. Sistimi ea metabolic ea phase II e ka hahuoa bocha ka motsoako oa li-microsomes tsa sebete le UGT mme ea sebelisoa ho ithuta botsitso ba karolo ea II ea bakuli ba lithethefatsi in vitro.

TS'ELISO HONA Eketsa kariking ea ho reka

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Tlhaloso ea lihlahisoa

Microsome｜Substrate｜ UGT Incubation System｜ 0.1M PBS (pH7.4)

Sehlopha:
Lisebelisoa tsa in vitro metabolism
Ntho NO.:
0112C1.01
Boholo ba Yuniti:
0.2mL * 50 teko
Tishu:
Sebete
Mefuta:
Beagle
Thobalano:
Monna
Maemo a polokelo le lipalangoang:
Boloka ho -70°C. Leqhoa le omileng le fanoa.
Mofuta oa tlhahlobo:
Phase II Metabolic Stability Kit (UGTs)
Sistimi ea Teko:
Microsome
Sebaka sa kopo:
Tlhahlobo ea In vitro ea Botsitso ba Metabolic

E fetileng: IPHASE Phase II Metabolic Stability Kit,Beagle

E latelang: IPHASE Phase II Metabolic Stability Kit,Monkey(Cynomolgus)

IPHASE Phase II Metabolic Stability Kit,Beagle

Tlhaloso e Khutšoanyane:

Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

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