Cynomolgus Monkey BMSC & CD34+ HSCs: Kayan aiki masu mahimmanci don Magungunan Farfaɗo & Jiyya

Mahimman kalmomi

Cynomolgus biri BMSC, cynomolgus biri CD34+ HPSC,Cynomolgus biri kasusuwan kasusuwa mesenchymal stromal Kwayoyin, cynomolgus biri CD34+ hematopoietic stem cell, wadanda ba - ɗan adam primate stem cell, regenerative medicine research, tissue engineering, hematopoietic reconstitution, stem cell transplantation, gene far preclinical model, cell far development.

IPHASE Products

Gabatarwa

Dabbobin da ba na ɗan adam ba, musamman birai na cynomolgus, suna raba sama da kashi 93 cikin 100 na homology na kwayoyin halitta tare da mutane, tare da tsarin sifofi iri ɗaya, tsarin rigakafi da tsarin ci gaban cuta. Su ne mafi yawan yarda da kuma amintattun samfura na asali don daidaita tazara tsakanin binciken dakin gwaje-gwaje da aikace-aikacen asibiti a cikin maganin tantanin halitta da kuma jiyya.

Daga cikin duk NHP-samuwar kayan halitta, kasusuwan kasusuwa-kwayoyin da aka samu sune aka fi amfani da su da kyaucynomolgus biri kasusuwa kasusuwa mesenchymal stromal selkumaCynomolgus biri CD34+ hematopoietic stem cell.

Menene cynomolgus biri kasusuwan kasusuwa mesenchymal stromal cells (BMSC)?

Cynomolgus biri na kasusuwa kasusuwa mesenchymal stromal (BMSCs)Kwayoyin stromal ne masu ƙarfi da yawa waɗanda aka samo daga kasusuwan kasusuwa na cynomolgus macaques. Wadannan kwayoyin halitta an san su da ikon su na yin amfani da filastik, fadada al'ada, da kuma bambanta cikin nau'i-nau'i masu yawa, irin su osteoblasts, adipocytes, da chondrocytes a ƙarƙashin yanayin da ya dace. Saboda rawar da suke takawa a cikin ƙananan ƙwayar kasusuwa, cynomolgus biri BMSCs ana amfani dasu sosai a cikin maganin farfadowa, injiniyan nama, rigakafi, da bincike na fassarar, suna samar da wani amfani maras - samfurin farko na ɗan adam don nazarin ci gaban cell, bambance-bambance, da ci gaban warkewa.

Menene cynomolgus biri kasusuwa kasusuwa CD34+ hematopoietic stem/progenitor cells (HSPC)?

Cynomolgus biri kasusuwan kasusuwa CD34+ hematopoietic stem/ HSPCsjini ne wanda bai balaga ba Suna bayyana alamar saman CD34, wanda aka saba amfani da shi don gano kara da yawan zuriya na farko tare da ikon sakewa da bambancewa cikin layin ƙwayoyin jini da yawa, gami da jajayen ƙwayoyin jini, ƙwayoyin farin jini, da platelets. A matsayin tushen asalin kwayar halitta wanda ba na ɗan adam ba, CD34+ HSPCs na cynomolgus ana amfani da su sosai a cikin ilimin halittar jini, ilimin halitta, ilimin halittar jiki, da binciken dasawa, inda suke aiki a matsayin samfuri mai mahimmanci don nazarin hematopoiesis, sake fasalin rigakafi, da tantanin halitta - aikace-aikace na warkewa.

Maɓalli Maɓalli

Duk da yake duka sun samo asali ne daga kasusuwa na biri na cynomolgus, waɗannan nau'ikan ƙwayoyin sel guda biyu suna da nau'ikan bambance-bambance daban-daban da ayyukan aiki, suna sa su dace da aikace-aikacen bincike daban-daban:

Aikace-aikace

1. Magungunan Farfaɗo & Injiniyan Nama

• Cynomolgus bir BM
• Gyaran ƙwayar tsoka: Haɓaka hanyoyin kwantar da hankali don maganin osteoarthritis, lahani na guringuntsi da karaya; Gyaran BMSC yana inganta haɓakar guringuntsi da inganta aikin haɗin gwiwa.
• Farfaɗowar zuciya na zuciya: Yi la'akari da inganci don ciwon zuciya da rashin ciwon zuciya; Kwayoyin sun bambanta cikin cardiomyocytes kuma suna ɓoye abubuwan angiogenic don haɓaka bugun jini na zuciya.
• Jiyya na Neurological: An yi amfani da shi a cikin bincike na farko na raunin kashin baya, bugun jini da cututtukan neurodegenerative; rage neuroinflammation da goyan bayan gyaran jijiyoyi.
• Warkar da raunuka & fibrosis: Nazarin tasirin warkewa akan raunuka na yau da kullun, hanta da fibrosis na huhu don tallafawa fassarar asibiti.

2. Sake Tsarin Hematopoietic & Dasa Kwayoyin Jiki

• Cynomolgus biri CD34+ HSPCs sune kayan aiki na farko da aka amince da su don nazarin dashen kwayar cutar hematopoietic, kawai maganin warkewa ga yawancin cututtukan jini da cututtukan jini:
• Haɓaka ka'idar HSCT: Gwada tsarin daidaitawa daban-daban, alluran tantanin halitta da hanyoyin isarwa don inganta haɓaka aikin haɓakawa da rage rikice-rikice kamar graft-kasancewar-cutar mai gida.
• Jini na igiya da dasawa a cikin haploidentical: Haɓaka hanyoyin faɗaɗa in vitro don haɓaka haɓaka ƙayyadaddun raka'o'in jinin igiya, magance ƙarancin masu ba da gudummawa a duniya.
• Ƙimar aminci na dogon lokaci: Saka idanu mai dorewa sake fasalin tsarin hematopoietic da yuwuwar kamuwa da cuta a cikin birai, samar da mahimman bayanan aminci don gwajin asibiti na ɗan adam.

3. Gene Therapy Research

• Dukansu BMSCs da CD34+ HSPCs sune maƙasudin sel masu manufa don maganin ex vivo genetherapy, magani mai canzawa don cututtukan ƙwayoyin cuta da kansa:
• CD34+ HSPC tushen ilimin halittar gado: Mafi kyawun dandamali na asibiti; inganta CRISPR
• Tsarin kwayoyin halittar BMSC: Yi amfani da su azaman motocin salula don sadar da kwayoyin warkewa kai tsaye zuwa ƙwayoyin da suka lalace; kimanta aminci, rarrabawar halittu da kuma tsawon lokaci - inganci don cututtuka masu lalacewa da ciwon daji.
• Ci gaban rigakafi: Ƙirƙirar kwayar halitta - CAR da aka gyara - T/CAR

Kammalawa

Cynomolgus biri BMSCs da CD34+ hematopoietic stem cell kayan aiki ne masu mahimmanci don haɓaka maganin farfadowa, aikin injiniya na nama da bincike na maganin kwayoyin halitta. Babban kamanninsu da sel masu tushe na ɗan adam yana tabbatar da cewa ainihin sakamakon da aka samu a cikin ƙirar biri na cynomolgus suna da ƙimar fassarar mafi girma ga gwajin asibiti na ɗan adam.

IPHASE yana ba da inganci mai kyau, da kyau - samfuran ƙwayoyin ƙwayoyin biri na cynomolgus tare da ƙayyadaddun tsari da cikakken bin ka'idoji. Ko kuna haɓaka sabbin hanyoyin kwantar da tarzoma, haɓaka ƙa'idodin dasawa ko inganta fasahar gyara kwayoyin halitta, samfuranmu na iya tallafawa bincikenku tun daga farkon ganowa zuwa ƙaddamar da IND na asali.

FAQs

1. Menene bambanci tsakanin cynomolgus biri BMSCs da CD34+ HSPCs?

BM-MSCs sune sel mai tushe na tsaka-tsakin tsaka-tsaki tare da bambancin jinsi da ayyuka na immunomodulatory, galibi ana amfani da su don gyaran nama. CD34+ HSPCs sel ne na layin hematopoietic waɗanda zasu iya sake kafa tsarin jini da tsarin rigakafi gaba ɗaya, galibi ana amfani da su don dasawa da jiyya.

2. Me yasa ake amfani da sel mai tushe na biri na cynomolgus maimakon linzamin kwamfuta ko ƙwayoyin jikin mutum?

Birai na Cynomolgus suna raba mafi girman kamanni na kwayoyin halitta da na jiki tare da mutane fiye da rodents, suna ba da ƙarin fayyace bayanai. Suna kuma guje wa lamuran ɗabi'a da ke da alaƙa da amfani da ƙwayoyin jikin ɗan adam.

3. Wane goyon bayan fasaha kuke bayarwa bayan siyan?

IPHASE yana ba da cikakken goyon bayan fasaha wanda ya haɗa da cikakkun ka'idojin al'adun cell, jagorar magance matsala, da ɗaya-a- shawara ɗaya tare da ƙungiyar kimiyyarmu. Hakanan zamu iya taimakawa tare da ƙirar gwaji da fassarar bayanai akan buƙata.