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IPHASE Phase II Metabolic Stability Kit,Rat(Sprague-Dawley)

Short Description:

Phase II metabolism, also known as the binding reaction, refers to the reaction in which phase I metabolites or prototype drugs combine with endogenous small molecules via phase II enzymes, leading to the reduction of toxicity, activity, or polarity of prodrugs. In phase II metabolism, the most common reaction is glucuronidation, during which the uridine diphosphate glucuronic acid (UDPGA) is bound to the prodrug via catalyzation by glucuronyl transferase in microsomes. The glucuronide formed increases water-solubility of metabolites to enhance the excretion. The phase II metabolic system can be reconstructed by combination of liver microsomes and UGT and used to study phase II metabolic stability of drug candidates in vitro.

Product Detail

Product Tags

  • Product discription

    Microsome|Substrate| UGT Incubation System| 0.1M PBS (pH7.4)

    • Category:
      In vitro metabolism kits
    • Item NO.:
      0112D1.02
    • Unit Size:
      0.2mL*50 test
    • Tissue:
      Liver
    • Species:
      Rat
    • Sex:
      Female
    • Storage conditions and transportation:
      Store at -70°C. Dry ice delivered.
    • Assay Type:
      Phase II Metabolic Stability Kit (UGTs)
    • Test System:
      Microsome
    • Scope of application:
      In vitro Assessment of Metabolic Stability

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