Lysosomes (Tritosomes): Waa saadaalin ah oo ku saabsan nidaamka tijaabada fiiyaaraha ee cudurka catroob-ga ama daraasadaha xasilloonida ee Lysosomal

Alaabada iphepape

HordhacLysosomes
LasoSome-ka waxaa soo ogaaday Christian wax laga ogaadeeyay sannadihii 1950-yadii waxaana loo aasaasay inuu yahay gole-ku-meel-gaarnimada dhexe ee xaalufinta iyo dheef-shiid kiimikaadka qolka. Lysosomes-ka waa hal-kelinimo - xuub, xuub, firfircoon, abaabulo abaabulo ah oo ku kala duwan goobta, morphology, cabir, cabir, enzyme-ka, iyo sunta. Xanuunka Lysosomal wuxuu ka kooban yahay boqolaal borotiinka xuubka xuubka ah, oo ay ku jiraan noocyo kala duwanGalayaaliyo kanaalada ion. Lysosontal Multic - Nulanit V - Atpase waxay sii soconaysaa anidic-ka lysosomal lumen. PH-ga hooseeya (4.5 - 5.5) wuxuu shaqeeyaa> 50) Lysosomes-ka ayaa hela oo dheef dheeli dheecaanka moleekul yar yar iyo alaabada endocyttoos ah, walxaha waaweyn ee 'stralf' sida apotenic cells-ka 'iyo tusaalooyin ku dhaca cytoplasria, oo ay kujirto mitochondsria, oo ay ku jiraan endoplasmium sterikoum, iyo restopomes. Sidaa darteed, Lysosomes-ka ayaa muddo dheer loo tixgeliyey "qashinka dib loo warshadeeyo" ee qolka.

Twitome

Trastosomes waa qaab-dhismeed hoosaadyo gaar ah oo ku takhasusay geedi socod kala duwan oo ka tirsan unugyada unugyada, gaar ahaan qaanuunka dariiqa dheef-shiid kiimikaadka iyo dayactirka unugyada gudaha ee guryaha loo yaqaan 'homeralas'. TRITOSOMES waxaa badanaa lagu bartaa macnaha guud ee doorkooda ay ku jiraan noocyo gaar ah oo unugyo ah. Qaybta qeexitaanka qaabdhismeedkaasi waa qaabkooda gaarka ah, kaas oo u oggolaanaya inay qabtaan shaqooyin wax ku ool ah oo muhiim u ah badbaadada iyo shaqada saxda ah ee unugyada. Jiirka beerka ee beerka waa Heptic Lysomes In lagu ridayey Tyloxapol (Triton Wr 1339), oo aan ahayn - ionic surwarant. Lysosomes-ka ay kujiraan Tylosapol Bandhigga cufnaanta yaraanta, waxay si hufan uga go'doomi karaan Mitochondria, oo ay ku sumoobaan unugyada unugyada ee cufnaanta dhalada dabiiciga ah.

Codsiga Lysosomes
· Daroogooyinka yar ee aashitada nucleic-ka iyo lysomomes
Daawooyinka yaryar ee nucleic acid waxay tixraacaan jajabyo yaryar oo nucleotides ah oo ay ku xiri karaan si gaar ah Mrnas gaar ah isla markaana ay farageliyaan waxtarka tarjumaadda ee Mrnas si ay ugu dambeyntii u guuleysato saameynta daweynta. Daawooyinka yar yar ee asaarada ah waxaa ka mid ah olidonecense oligonucleides (Asos), Sirna), ee 'Mirrna', 'Mirrna', ASO), ASO iyo Sirna, ASO iyo Sirna waa jihooyinka cilmi-baarista ee hadda jira ee dawooyinka naasaha ee hadda jira.

Maamulka ka dib, daroogada yaryar ee nucleic acid marka hore waxay u baahan yihiin inay ka fogaadaan nabaad-guurka ee loo yaqaan 'plasiosis', oo ay ku celceliyaan endokoplasm-ka, oo ay ku darsadaan bartilmaameedka Mrna si aad u gaarto aamusnaanta Mrna si aad u gaarto aamusnaanta hidda-wadaha. Lysosomes-ka waxaa loo isticmaali karaa nidaam tijaabo oo hufan oo lagu qiimeeyo isbedelada xasilloonida dawooyinka yar yar ee aashitada nussomes ee vitro, oo siiya taageero xog ah oo ku saabsan cilmi-baarista aashitada yar yar ee nucloic.

· Daawooyinka daroogada ah - daroogada conjugate (ADC) iyo Lysosomes
Daawada ka hortagga (ADC) waa nooc cusub oo daroogada bayoolajiga ah ee lammaanayaasha ku jira xeryahooda yar yar ee molales-ka ah ee lagu beegsado unugyada jirka ka hortaga jirka ama jajabyada ka hortaga antibody-ka iyadoo la adeegsanayo isku xirka. Waxay xoojin kartaa bartilmaameedka daroogada iyo xasilloonida, yareynta sunta kiliinikada iyo waxyeelooyinka, iyo hagaajinta tusmada daweynta. Waxay leedahay labada dilka ee daroogada yar yar ee molekal-ga ee yar yar iyo bartilmaameedka dawooyinka ka hortaga antibodynta. Waxaa inta badan loo isticmaalaa daaweynta la bartilmaameedsado ee ku-hortagga burada ama cudurada kale.

Ka dib markii la soo galay jirka, molekuluska ADC waxay ku xiri karaan antigens dusha sare ee unugyada bartilmaameedka ah iyada oo la siinayo unugyada unugyada ka hortagga monoclonal, iyo wareejinta kale ee loo maro unugyada bartilmaameedka. Moleculeyaasha ADC ee gala unugyada (badiyaa Lysomes-ka) waxay sii deyn karaan sunta yar-yar ee molecule-ka (ama sunta analogs (i.e.,,,,,,, injiinka moleekulka) oo ah kiimiko iyo / ama ficil enzymatic ah "dil" unugyada bartilmaameedka ah. ADC waxay u baahan tahay lysosomes-ka shaqeysa si ay u burburiyaan oo ay sii daayaan dawooyinka moleelka yar-yar ee wax ku ool ah oo ka soo baxa xuubka 'Lysosomal' ama ka soo baxaan xuubka 'Lysomes', oo ay la falgalaan bartilmaameedka mossomalar ee ku jira cytoplasm ama nucleus. Baadhitaanada vitro ee ADC iyo Lysomes-ka ayaa qiimeyn ku sameyn kara haddii xiriiriyeyaasha si hufan loo jaro haddii ay u sii daayaan daroogada yar-yar ee loo yaqaan 'proselale moleule' ay qaadaan, iyadoo la siinayo aalad qiimeyn yar oo qiimeyn ah oo loogu talagalay naqshadda xinjirka ADC.

Ku saabsan iphage
Iyada oo ah hogaaminta hogaaminta bayoolojiga ee ku saabsan vital bayoolojiga ee horumarka daroogada, iphape-ka ayaa bilaabay beerka wax soo saarka leh ee shan nooc, oo ay kujiraan koox joogto ah iyo soosaarid ah, oo ku tiirsanaysa kooxdeeda iyo soosaarka, ee ku caawinaya horumarinta daroogada.
Firfircoonaanta Enzyme Sare: iPhepape beerka beerka ee kastomemes-ka ayaa laga baaray ee Cathepsin B iyo aashitada dhaqdhaqaaqa fosfoonka, waxqabadka enzyme-ka waa u isbarbardhigayaa ama ka sareeya waxyaabaha la soo dejiyey.
· Soosaarka dufcaddu: wax soo saarka dufcaddu waa la qaatay, oo alaabada ayaa ku filan in la hubiyo saadka isla badeecadaha la mid ah.
Waqti gaarsiin gaaban: Daraasad madax-bannaan oo madaxbanaan iyo horumar, bakhaarro kala duwan oo lagu keydiyo, si loo hubiyo baahiyaha isticmaalka macaamiisha.