PDC waxay ku xisaabtantaa sifooyinka molecules waaweyn iyo kuwa yaryarba.Sidaa darteed, in vitro ADME cilmi-baaris ku saabsan waxay u baahan tahay in la tixgeliyo homing peptides, linkers, loadloads, iyo PDC.Marxaladaha hore ee horumarinta daroogada, haddii homing peptide uu ku jiro qaabka daawada polypeptide, waxay u nugul tahay hydrolysis waxayna leedahay xasillooni liidata. Degganaanshaheeda iyo bartilmaameedka plasma waa in la tixgeliyaa; Isla mar ahaantaana, labada nooc ee xiriiriyaha ayaa soo saari doona natiijooyin kala duwan oo dheef-shiid kiimikaad ah, iyo culeyska la sii daayay (oo ay ku jiraan culeyska ku xiran qaybta isku midka ah ee isku xiraha) waa daroogada cytotoxic molecule yar. Waa muhiim in la go'aamiyo dheef-shiid kiimikaad ee daawooyinkan horumarinta daroogada. Sidaa darteed, PDC oo ka kooban homing peptides, linkers, iyo loadloads waxay u baahan yihiin in lagu barto xasiloonida balasmaha, borotiinka plasma, aqoonsiga dheef-shiid kiimikaadka, iwm, taas oo muhiimad weyn u leh horumarinta hore ee daawooyinka PDC!
IPHASE "Hal - joogsi ah" xalka badeecada ee cilmi baarista gudaha vitro DMPK
Hogaamiye ku jira dib-u-hagaajinta bayooloji ee in vitro, IPHASE waxay raacdaa safka hore ee horumarinta daroogada waxayna horumarisaa noocyo kala duwan oo reagents noolaha noolaha ee heerar kala duwan iyo goobo lagu beegsanayo in vitro DMPK jihada cilmi-baarista ee dawooyinka PDC si ay u caawiyaan PDC cilmi horumarinta daroogada!
1.Subcellular reagents jajabka
·Microsomes beerka ·Beerka S9/ Beerka Acidified S9
·Beerka cytosol ·Kelyaha S9
·Lysosome Isku-soo-baxa beerka aysiidhaysan
2.Alaabooyinka Hepatocyte Primary
Bani'aadam/Daayeer/Ey/Jiir/Jiir/Diyaarad Yaryar Oo Lalaalay/Ku Xidhan AasaaskaHepatocytes
3.Transporter Products
· Gaadiidleyda qoyska ABC ·SLCgaadiidka qoyska
4.Recombinant alaabta enzyme
·CYP ·UGT
5.Alaabooyinka la xidhiidha Plasma
Qalabka sifaynta dheellitirka ee dheellitirka · Alaabta tijaabada xasiloonida balasmada
Soo celinta borotiinka balaasmada
6.Blank matrix bayoloji
Waqtiga boostada: 2024-08-16 15:26:10