mamela konteraka", ho latela tlhokahalo ea mmaraka, e kenela tlholisano ea 'maraka ka boleng ba eona bo holimo joalo ka ha e fana ka k'hamphani e felletseng le e kholo bakeng sa bareki ho ba lumella ho ba bahlodi ba bangata.setho sa batho, thipa ea likaroloana tsa matšoafo S9, C57BL/6 mouse serum serum, tshwene PBMC kit. Re amohela ka tieo baeti bohle ho theha likamano tsa khoebo le rona motheong oa melemo ea bobeli. Ka kopo ikopanye le rona hona joale. U tla fumana karabo ea rona ea setsebi nakong ea lihora tse 8. Ka boiteko ba ho tsamaisana le mokhoa oa lefats'e, re tla lula re leka ho fihlela litlhoko tsa bareki. Haeba u batla ho hlahisa lintho tse ling tse ncha, re ka li etsa hore li lumellane le litlhoko tsa hau. Haeba u ikutloa u thahasella lihlahisoa leha e le life tsa rona le tharollo kapa u batla ho hlahisa thepa e ncha, u lokela ho ikutloa u lokolohile ho ikopanya le rona. Re labalabela ho theha likamano tse atlehileng tsa khoebo le bareki lefatšeng ka bophara.thipa ffpe kit, PBMC ea ho itšehla thajana, monkey serum kit, moltox s9 kit.
In vivo alkaline comet assay e ntse e sebelisoa haholo tlhahlobong ea genotoxicity ea metsoako. ICH S2 (R1) e kenyelelitse tlhahlobo ea comet ea sebete e le tlhahlobo ea 2nd in vivo bakeng sa li-tissue / endpoints; e
Ho aroloa ha Peripheral Blood Mononuclear Cells (PBMC) ke mokhoa oa bohlokoa lipatlisisong tsa biomedical le lits'ebetsong tsa bongaka. Lisele tsena li kenyelletsa li-lymphocyte (mohlala, lisele tsa T, lisele tsa B, lisele tsa NK) a
SelelekelaT lisele ke karolo ea bohlokoa ea sesole sa 'mele, se bapala karolo ea bohlokoa ho khethollang le ho loants'eng likokoana-hloko. Ts'ebetso ea ts'ebetso ea T cell ke mokhoa o rarahaneng, oa mehato e mengata
PDC in vitro ADME ea mohlala oa lipatlisiso PDC e nahanela litšobotsi tsa limolek'hule tse kholo le tse nyane. Ka hona, lipatlisiso tsa in vitro ADME ka eona li hloka ho ela hloko li-peptide tsa homing, link
Haufinyane tjena, IPHASE, mmoho le Perelman School of Medicine Univesithing ea Pennsylvania, e ngotse sengoloa koranteng ea Antibody Therapeutics (IF=4.56) e nang le sehlooho se reng "Ntšetso-pele ea
SOT ea bo-63 e felile ka mokhoa o phethahetseng, 'me thabo ea IPHASE-US ha e fele!The 63rd Annual Meeting and Exposition of the American Society of Toxicology e ile ea tšoaroa ka katleho ho tloha ka March 10-14, 2024, ka.
Ho fana ka nako e nepahetseng, ts'ebetsong e tiileng ea litokisetso tsa konteraka ea thepa, e ile ea kopana le maemo a khethehileng, empa hape e sebelisana ka mafolofolo, k'hamphani e tšepahalang!
Ka sebele ke lehlohonolo ho fumana moetsi ea joalo oa setsebi le ea nang le boikarabelo, boleng ba sehlahisoa bo botle 'me ho pepa ho nakong, ho monate haholo.
Khamphani ena e lumellana le tlhokahalo ea 'maraka' me e kenela tlholisano ea 'maraka ka sehlahisoa sa eona sa boleng bo holimo, ke khoebo e nang le moea oa Sechaena.
Ena ke k'hamphani e nang le botumo bo botle, ba na le boemo bo phahameng ba tsamaiso ea khoebo, sehlahisoa sa boleng bo botle le tšebeletso, tšebelisano e 'ngoe le e' ngoe e tiisetsoa ebile e thabile!