PDC e nahanela litšobotsi tsa limolek'hule tse kholo le tse nyenyane.Ka hona, lipatlisiso tsa in vitro ADME ho eona li hloka ho ela hloko li-peptide tsa homing, lihokela, litefo, le PDC.Mehatong ea pele ea nts'etsopele ea lithethefatsi, haeba peptide ea homing e le ka sebopeho sa sethethefatsi sa polypeptide, e na le hydrolysis mme e na le botsitso bo fokolang. Ho tsitsa ha eona le sepheo sa eona ho plasma ho lokela ho nkoa; ka nako e ts'oanang, mefuta e 'meli ea sehokelo e tla hlahisa liphetho tse fapaneng tsa metabolic,' me moputso o lokollotsoeng (ho kenyeletsoa le moputso o amanang le karolo e le 'ngoe ea sehokelo) ke molek'hule e nyane ea cytotoxic lithethefatsi. Ho bohlokoa ho tseba hore na metabolite ea lithethefatsi tsena ke efe bakeng sa nts'etsopele ea lithethefatsi. Ka hona, PDC e entsoeng ka li-peptide tsa homing, li-linkers, le li-payloads li hloka ho ithutoa ka botsitso ba plasma, ho tlama ha protheine ea plasma, ho tsebahatsa metabolite, joalo-joalo, e leng ea bohlokoa haholo bakeng sa tsoelo-pele ea pele ea lithethefatsi tsa PDC!
IPHASE "One-stop" tharollo ea sehlahisoa bakeng sa lipatlisiso tsa in vitro DPK
E le moetapele oa in vitro ho etsa lipatlisiso li-reagents tsa baeloji, IPHASE e latela sehlohlolong sa nts'etsopele ea lithethefatsi mme e nts'etsapele mefuta e fapaneng ea li-in vitro biological reaagents maemong a mangata le masimong a shebileng tataiso ea lipatlisiso tsa in vitro DMPK ea lithethefatsi tsa PDC ho thusa lipatlisiso tsa nts'etsopele ea lithethefatsi tsa PDC!
1.Subcellular fraction reagents
·Li-microsome tsa sebete ·Sebete S9/Acidified Sebete S9
·Cytosol ea sebete ·Liphio S9
·Lysosome · Homogenate ea sebete e nang le asiti
2.Lihlahisoa tsa mantlha tsa Hepatocyte
·Motho/Tšhwenene/Ntja/Legotlo/Legotlo/Nyonyane e Emisitswe/Adherent PrimaryHepatocytes
3.Lihlahisoa tsa Lipalangoang
·Lipalangoang tsa malapa tsa ABC ·SLCbapalami ba malapa
4.Recombinant enzyme lihlahisoa
·CYP ·UGT
5.Lihlahisoa tse amanang le Plasma
·Disebediswa tsa dialysis tsa tekatekano ·Dihlahiswa tsa teko ya plasma stability
·Lisebelisuoa tse tlamang protheine ea plasma
6.Matrix ea tlhaho e se nang letho
Nako ea poso: 2024-08-16 15:26:10