Tsis ntev los no, kev ua haujlwm nrog cov tshuaj perelman ntawm cov ntawv sau tshuaj tiv thaiv anti - antergic antibody thiab antity Antibody HZ - 1127 thiab sim nws txoj kev sib tsoo ib puag ncig, qhov tshwj xeeb thiab kev muaj peev xwm cuam tshuam rau TSLP.
Thymic stromal lymphopoietin (TSLP) yog ib tus tswv cuab ntawm Phau Ntawv MaumoosIL - 2 CYTOKINETsev neeg, thiab siv cov nqi ntawm TSLP Yog li ntawd, khi lus los ntawm Tslp siv tshuaj tiv thaiv yog lub tswv yim zoo rau kev kho cov kab mob thiab cov qog nqaij hlav. FDA tam sim no pom zoo tezepelumab, tib neeg anti - Tslp tshuaj tiv thaiv mioclonal, rau kev kho mob hawb pob.
Qhov chaw IPAS tau tsim thawj zaug hauv kev kawm no ib tug tib neeg kev txhim kho tshiab, tslp antiinity thiab tshwj xeeb rau kev xaiv tsa CIN TSLP cytokines. Piv nrog tezepelumab, cov epitopes khi rau tslp los ntawm ob qho tib si yog zoo sib xws, thiab HZ - 1127 muaj lub zog muaj zog los thaiv kev sib cuam tshuam ntawm TSLP thiab TSLPR. HZ - 1127 kuj tseem pom cov teebmeem zoo dua rau kev ua haujlwm rau tslp - Tus neeg kho kom haum
Cov tshuaj tiv thaiv kev txhim kho cov tshuaj tiv thaiv kev txhim kho hauv txoj kev kawm no thiab cov tshuaj tua neeg nyiam thiab cov tshuaj tiv thaiv siv hauv kev sim tau muab los ntawm Minhase.
Fig.1 Kev Qhia Txog Monoclonal Antibody Hz - 1127
Figer.2 Inhibition ntawm Tslp - Txim CCL17 thiab CCL22 chemokine zais cia allcovezed nyob rau hauvPBMCs
Fig.3 schematic sawv cev ntawm lub inisabitos nyhuv ntawm HZ - 1127 thiab tezepelumab ntawm tslp signaling
Thymic stromal lymphopoietin (TSLP) yog ib tus tswv cuab ntawm Phau Ntawv MaumoosIL - 2 CYTOKINETsev neeg, thiab siv cov nqi ntawm TSLP Yog li ntawd, khi lus los ntawm Tslp siv tshuaj tiv thaiv yog lub tswv yim zoo rau kev kho cov kab mob thiab cov qog nqaij hlav. FDA tam sim no pom zoo tezepelumab, tib neeg anti - Tslp tshuaj tiv thaiv mioclonal, rau kev kho mob hawb pob.
Qhov chaw IPAS tau tsim thawj zaug hauv kev kawm no ib tug tib neeg kev txhim kho tshiab, tslp antiinity thiab tshwj xeeb rau kev xaiv tsa CIN TSLP cytokines. Piv nrog tezepelumab, cov epitopes khi rau tslp los ntawm ob qho tib si yog zoo sib xws, thiab HZ - 1127 muaj lub zog muaj zog los thaiv kev sib cuam tshuam ntawm TSLP thiab TSLPR. HZ - 1127 kuj tseem pom cov teebmeem zoo dua rau kev ua haujlwm rau tslp - Tus neeg kho kom haum
Cov tshuaj tiv thaiv kev txhim kho cov tshuaj tiv thaiv kev txhim kho hauv txoj kev kawm no thiab cov tshuaj tua neeg nyiam thiab cov tshuaj tiv thaiv siv hauv kev sim tau muab los ntawm Minhase.
Fig.1 Kev Qhia Txog Monoclonal Antibody Hz - 1127
Figer.2 Inhibition ntawm Tslp - Txim CCL17 thiab CCL22 chemokine zais cia allcovezed nyob rau hauvPBMCs
Fig.3 schematic sawv cev ntawm lub inisabitos nyhuv ntawm HZ - 1127 thiab tezepelumab ntawm tslp signaling
Lub Sijhawm Post: 2024 - 07 - 27:34:37