Nā hōʻike hōʻike maʻamau
ʻO ka hōʻike amenes ka mea i hoʻohana nuiʻia no ka nānāʻana i ka pōʻino e hiki ai i nā mea hoʻohuihui e pili ana i nā compurical a me nā n - Nitrosines. ʻOiaiʻo kona manaʻo i loko o ke kiʻiʻana i ka trixicological, he mau palena o ka hōʻike maʻamau, he nui i ka wā e koi ai i ka hoʻohuiʻana o ka hoʻohuiʻana i ka hoʻohuiʻana i ka metabola.
Nā palena o ka hōʻike hōʻike maʻamau
ʻOiai ke kauʻana o ka hōʻike ames i kahi corsesttone ma ka ho'āʻoʻana i ka hōʻikeʻana, he mau palena:
- Hoʻopau i ka hoʻohanaʻana i ka metabolic
ʻO ka hōʻike maʻamauʻo ASES i hoʻohana pinepineʻia e hoʻohana pinepine iā Rat Liver S9, e lacks i kekahi kanaka kanaka.ʻO Cytochrome P450 Hiki i kēia ke alakaʻi i lalo o nā procarcinogens Hōʻike: Rat S9 maikaʻiʻole metabilizes n - NITROSDIEIETYMINE (NDEO) i hoʻohālikelikeʻia i nā'ōkuhi kanaka.
- Hoʻolaha i ka URITAT Spectrum Spectrum:
Nā Kūlana Kūlana (E.G., Ta98, Ta98, Ta100) E nānā i nāʻano hana pilikino kūikawā (Framsishit.
- Over -
ʻOiai e hoʻohana ana i ka hōʻikeʻo SalmonLe Tyhimola nui,ʻaʻole ia e pili ana i nā mechanis āpau i kēia manawa mammano lake.
- Nā hewa hewa a me nā Negative:
ʻO kekahi mau mea kūʻai aku non - Nā helu muteragenic e hāʻawi i nā hopena maikaʻi ma muli o nā pane kaumaha loa,ʻoiai e koi ana kekahi mau mika e koi ana i ka hana paʻakikī
ʻO ka ho'āʻoʻana i ka Ames
Hōʻike houʻo Ema i ka QU & AS GUIDANTERS e pili ana i keʻano haʻahaʻa o kekahi mau hōʻike no nā mea hana a me ka makemake o FDA. Ua hoʻopau ka FDA i nāʻano hana maʻamau i hoʻohanaʻia no ka hōʻikeʻana o nā hōʻike a me nā hopena maikaʻiʻole e hana i nā hopena maikaʻiʻole no ka hopena maikaʻiʻole. I ka paneʻana, ke kikowaena o ka'āinaʻo FDA no ka noiʻiʻana i nā mea noiʻi e ho'āʻo ai i nā loiloi e hoʻonui ai i ka loiloi o ka mokuahi e hoʻonui ai i ka loiloi nui o ka mika.
ʻO nā hōʻike e hoʻonui nei i nāʻano a me nā kūlana
|
Nā Launa Hoʻo ho'āʻo |
Komo pū me salmonella tyhimrium ta98, ta100. Ta1535, ta15337 a mascherchilia coli Wp2 uvra (pkm101) strain ho'āʻo |
|
Hōʻike hōʻike a me ka mua. |
Ua hoʻohanaʻiaʻo Pre - Insulation a me Non - Nā Kūlana FlackbodDing e hoʻohanaʻia, me kahi mea i manaʻoʻiaʻo Privated Prepaication. |
|
S9ʻano a me ka nānāʻana |
E hanaʻia nā hōʻike AES ATES i loaʻa i ka 30% Rat Liver S9 a me 30%Hamster Little S9. ^. E hoʻomākaukauʻiaʻo Rat a me Hamster Desmonmal (S9S) e hoʻomākaukauʻia mai nā mea a me nā mea a nā roltcytochrome p450 enzyme- e hoʻopili ana i nā mea (e.g., kahi hui pūʻana o ka phenorbital a β - naphflavone). |
|
Maikaʻiʻole (refvent / reclipient) |
Pono nā mea hana i hoʻohanaʻia e kūpono me nā hōʻike a me nāOEC00 471Nā alakaʻi alakaʻi. Loaʻa nā mea i loaʻa i nā mea e komo ai, akāʻaʻole i kaupalenaʻia: (1) wai; (2) nā mea hoʻokele kūloko e like me ka Acetotitrile, Methanol Ke hoʻohanaʻia nei nā mea hoʻokele Organik,ʻo ka helu haʻahaʻa haʻahaʻa loa i ka mua o ka mua. Pono e hōʻikeʻia ka nui o ka hoʻohanaʻana i ka nui o ka metabolina. |
|
Ka mana kūpono |
Wahi a OECD 471 alakaʻi alakaʻi, strain - pono e hanaʻia nā mana kūpono kūpono i ka manawa like. I ka heleʻana o S9,ʻo nā meaʻelua n - Nitrosamnes iʻikeʻia e lilo i mika e like me nā mana kūpono. ʻAiʻia n - NolSsamine Nā Mālama Maikaʻi: |
|
Pono nā'ōlelo āpau a pau ma nā manaʻo a me nā mea hoʻoponopono a me nā kulekele OECT 471 |
|
ʻO ka hana kūʻokoʻa o ka Hamster Liver S9 Fraction
He waiwai nui loa ka hapa nui o ka momster s9 i ka ho'āʻoʻana ma muli o kona hoʻomauʻana ma muli o kona hiki ke hana i kekahi o nā mea hiki ke ho'āla i kahi o nā mode n? E wāwahi ana ia i kahiʻaoʻao metabolic metabolic i nā mea enzymes o ke kanaka, e hana hou ana no ka loiloi o ke kanaka. Hoʻopiliʻia, nā mea nui o ka hamster s9 i loaʻa nā kiʻekiʻe kiʻekiʻe o nā pihi P450 o CYTOCHORME P450 ʻO kēia mau hopena i ka hoʻomaikaʻiʻana i kaʻike maikaʻi a hōʻemi i ka hewa.
Hopena
ʻOiai e waiho ana ka hōʻikeʻo Ames Anes i kahi mea hana kumu no ka loiloiʻana i ka mikana,ʻo kona mau palena e pono ai i nā hoʻomaikaʻi maikaʻi. ʻO ka hōʻikeʻana o nā hōʻike Ames i hoʻonuiʻia, me ka hoʻopiliʻana o ka Hamster Liver Liver S9 Fraction Hāʻawi kēia holomua i kahi ala kūpono hou aʻe no ka loiloiʻana i nā carcinogens kanaka a me ke kākoʻoʻana i ka hoʻoponopono houʻana i nā hoʻoponopono hou.
Nā hua'ōlelo: n - NITSORAMINES, NDSRIS, OCDD 471, Hoʻonuiʻia nā hōʻikeʻo S9ster S9
Nā manawa pā: 2025 - 03) 03 - 12 09:22:09