Nekukura kwekuenderera kweBiotechnology, kusimudzira kweanunakidza zvinodhaka zvakaita semishonga madiki, pakati peiyo Sirna / Sarudzo dzeSirna. MuVitro bvunzo dzinodiwa kuongorora kugadzikana uye kuchengetedzeka kwemishonga, uyelysosomesIzvo zvakakosha muVitro metabolism yekutsvaga zvigadzirwa mukuvandudza kweSirna / rnai uye adc zvinodhaka.
Zvigadzirwa zvePhase
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Item Nha. |
Chigadzirwa Zita |
Kutaurwa |
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Pirahase munhu chiropa chombo mansosomes, akasanganiswa wechikadzi |
250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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A - 1 ML, B - 10 μL |
Nhanganyaya kune Lysosomes
LysosomesVari vasina murume Lysosomes ane maumbirwo akasiyana-siyana, kazhinji vesicular zvivakwa zve0.02 - Hydrolytic enzymes ndeye 3.5 - 5.5.in-5.infunga nezvematare evaLysosomes uye nharaunda yakashanda.
Dhizaini yeRysosomes. Mufananidzo wakagadzirwa neFigKow.
Hunhu hwe lysosomes
Sekurasikirwa kweiyo ssosomes vanoshanda mumatunhu acidic, enzymes yavo ine maitiro matatu:
1) Iyo lysosomal pamusoro yakanyanya glycosylated, inozvibatsira kuzvidzivirira kubva ku enzymatic hydrolysis. Mapuroteni emapuroteni anonyanya kubhururuka, uye nzvimbo yemukati yeiyo Lysosomal membrane haina mhosva, iyo inobatsira ma enzymes muRysosomes kuti arambe akasununguka. Izvi zvakakosha pakushandisa basa rakajairika uye kudzivirira iyo cell pachako kubva pakucherwa;
2) ese hydrolytic enzymes ari kunyatso shandura paPH = 5, asi vaCytoplasm yavo ine ph = 7.2. Iyo Lysosomal membrane ine inokosha yekutakura mapuroteni iyo inogona kushandisa simba reATP hydrolysis kuti pump h + (hydrogen ion) kubva kuCytoplasm muRysosomes kuitira kuti varambe vaine ph = 5;
3) Iwo ma enzymes muRysosomes anoshandisa basa ravo chete kana chinhu cheHydrolyzed chinopinda maLsosomes. Kamwe chete iyo lysosomal membrane inobviswa uye iyo hydrolyzing enzymes kupukunyuka, cellular autolis ichaguma.
Basa uye kuiswa kwelysosomes
Basa guru revaLysosomes, nhengo inonakidza yekugaya, uye celluly Basa rayo rekuita rakapetwa kaviri, kureva kuti, kuparadzaniswa nevesicles dzekudya kuti vadye muBiomolecules uye kugaya kweSenescent organteles
Lysosomes anogona kukamurwa kuva yekutanga lysosomes, sekondari lysosomes uye yakasara muviri zvinoenderana nematanho akasiyana ekuzadzisa mabasa avo emuviri.
Kutumira Nguva: 2024 - 11 - 05 14:19:09