Ndi chitukuko mosalekeza kwa biotechchnology, kukula kwa mankhwala osokoneza bongo monga mankhwala ang'onoang'ono ndi biolotives ndi biologics apanga zosankha zodziwika bwino komanso zosankha za mankhwala ambiri a antiraker. Mu mayeso a vitro ndikofunikira kuti ayang'anire kukhazikika ndi chitetezo cha mankhwala, ndipoLysosomesndizofunikira kwambiri ku Vicro metabolism preassecker pa chitukuko cha Sirna / Rnai ndi mankhwala a ADC.
Zinthu za Iphase
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Chinthu Ayi. |
Dzina lazogulitsa |
Chifanizo |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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250 μL, 2 mg / ml |
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A - 1 ml, b - 10 μl |
Kuyamba kwa Lyshosomes
Lysosomesndi osakwatiwa - membrane organelles m'maselo a Eukaryotic omwe amaphwanya Biomolecles, ma acid a asing'anga, ndipo adapezeka koyamba ku Cristian Cristian De SUve (1917 - 2013) ndi ena. Lysosomes ali ndi mawonekedwe osiyanasiyana, nthawi zambiri zimapangidwa ndi zida za 0.025 - 0,8 μm. Michere ya hydrolylytic ndi 3.5 - 5.5 - 5.5
Chojambula cha ma lysosomes. Chithunzi chopangidwa ndi Njiwa.
Makhalidwe a Lysosomes
Monga Lushosomes omwe amagwira ntchito m'magawo acidic, minyewa yawo ili ndi mikhalidwe itatu:
1) Malo a lysosomal amakhala okwera kwambiri, omwe amathandiza kudziteteza ku Enzymatic hydrolysis. Ma protein a membrane ali glycophrotein, ndipo mchere wamkati wa neysosomene wa nesosomal saimbidwa mlandu, womwe umathandizira ma enzymes kuti asamasuke. Izi ndizofunikira kuti mugwiritse ntchito ntchito yabwinobwino komanso kupewa khungu kuti lisagawidwe;
2) Mitsempha yonse ya Hydrolytic imagwirabe ntchito pafupifupi pH = 5, koma ma cytoplasm omwe ali mozungulira ali ndi PH = 7.2. Nesosomal membrane ali ndi mapuloteni apadera omwe amatha kugwiritsa ntchito mphamvu ya ATP Hydrolysis kuti athe kupukusa H +
3) Ma enzymes m'mabwenyetse amagwiritsa ntchito bwino ntchito yawo pokhapokha ngati mankhwala a hydrolyzed amalowetsa ma lyyosomes. Jendosomal membrane akangowoledwa ndipo ma enzyming enzymes amathawira, ma cell autolysis adzachokera.
Ntchito ndi gulu laLysosomes
Udindo waukulu wa Lysosomes ndi chimbudzi, umerracelyar chigawenga, ndi ma cell Autolysis, chitetezo, ndi kugwiritsa ntchito zinthu zina zomwe zimagwirizana ndi chimbudzi. Ntchito yake yayikulu ndi iwiri, yomwe inkasinthana ndi zakudya zoyatsira chakudya kukhala chakudya mu bisonesisple kapena biomoleclules opangidwa ndi chilengedwe.
Maysosomes amatha kugawidwa kukhala ma lysosomes oyamba, lysosomes yachiwiri komanso thupi lotsalira malinga ndi magawo osiyanasiyana omwe akwaniritsa ntchito zawo zathupi.
Post Nthawi: 2024 - 11 - 05 14:19:09