PDC rationem accipit indoles tam magni quam minoris moleculae.Itaque in inquisitione vitro ADME oportet considerare homing peptides, nexus, payloads, et PDC.In primis medicamentis evolutionis stadia, si peptidium homing in polypeptide medicamento est, prona est ad hydrolysim et pauperem stabilitatem habet. Eius stabilitas et nisl in plasma considerari debent; simul duae formae iungentis varios eventus metabolicos efficient, et payload solutum (incluso payload eidem parti nexae coniuncta) est medicamentum parvum moleculae cytotoxicum. Metabolites horum medicamentorum medicamentorum evolutionis determinare pendet. Ergo PDC composita ex peptidis homing, nexus, et payloads oportet considerare in plasma stabilitatis, interdum ligaturae, identitatis metabolitae, etc., quod magni momenti est pro primis medicamentis PDC evolutionis!
IPHASE "Unus-stop" productum solutioni in vitro DMPK research
Sicut dux in vitro investigationis biologicae reagentias, IPHASE frontem medicamentorum progressionem sequitur et varias in vitro biologico regentes in multiplicibus gradibus et campis nisus in vitro DMPK investigationis directionis PDC medicinae ad auxilium PDC medicamentorum evolutionis investigationem!
1.Subcellular fraction reagentia
·Microsomes iecur ·Jecur S9/Acidified Jecur S9
·Jecur cytosol ·Renum S9
·Lysosome · iecur homogenatum acidificatum
2.Primary Hepatocyte Products
· Humanus/Simius/Canis/Rat/Mus/Minipig Intermissa/Adhens PrimariusHepatocytes
3.Transporter Products
·ABC transporters familia ·SLCfamilia transporters
4.Recombinant enzyme products
·CYP ·UGT
5.Plasma products related
·Aequilibrium dialysis adinventiones ·Plasma stabilitas productorum testium
·Plasma reagentis ligamen
6.Blank matrix biologica
Post time: 2024-08-16 15:26:10