PDC coj mus rau hauv tus account tus yam ntxwv ntawm ob qho tib si loj thiab me molecules.Yog li ntawd, nyob rau hauv vitro ADME kev tshawb fawb ntawm nws yuav tsum tau coj mus rau hauv tus account homing peptides, linkers, payloads, thiab PDC.Nyob rau theem pib ntawm kev txhim kho tshuaj, yog tias homing peptide nyob rau hauv daim ntawv ntawm cov tshuaj polypeptide, nws yog nquag hydrolysis thiab tsis zoo stability. Nws txoj kev ruaj ntseg thiab lub hom phiaj hauv plasma yuav tsum raug txiav txim siab; tib lub sijhawm, ob hom kev sib txuas yuav tsim cov txiaj ntsig metabolic sib txawv, thiab cov khoom tso tawm (suav nrog cov payload txuas nrog tib qho ntawm cov linker) yog cov tshuaj cytotoxic me me. Nws yog ib qho tseem ceeb los txiav txim siab cov metabolites ntawm cov tshuaj no rau kev txhim kho tshuaj. Yog li ntawd, PDC muaj xws li homing peptides, linkers, thiab payloads yuav tsum tau kawm nyob rau hauv plasma stability, plasma protein binding, metabolite identification, thiab lwm yam, uas yog ib qho tseem ceeb heev rau txoj kev loj hlob ntawm cov tshuaj PDC thaum ntxov!
IPHASE "Ib qho - nres" cov khoom lag luam rau kev tshawb fawb hauv vitro DMPK
Raws li tus thawj coj hauv kev tshawb fawb hauv vitro tshuaj lom neeg reagents, IPHASE ua raws li cov thawj coj ntawm kev tsim tshuaj thiab tsim ntau yam hauv vitro lom reagents ntawm ntau theem thiab thaj chaw tsom rau kev tshawb fawb hauv vitro DMPK cov kev taw qhia ntawm PDC cov tshuaj los pab PDC kev tshawb fawb tshuaj!
1.Subcellular feem ntau reagents
·Lub siab microsomes ·cev S9/Acidified daim siab S9
·Lub siab cytosol ·Lub raum S9
·Lysosome · Acidified daim siab homogenate
2.Primary Hepatocyte Khoom
· Tib neeg / Liab / Aub / Nas / Nas / Minipig Suspended / Adherent PrimaryHepatocytes
3. Cov khoom thauj khoom thauj
· ABC tsev neeg thauj ·SLCtsev neeg thauj
4.Recombinant enzyme khoom
·CYP ·UGT
5.Plasma ntsig txog cov khoom
· Equilibrium dialysis li · Plasma stability test khoom
· Plasma protein binding reagents
6.Blank lom matrix
Hnub tim: 2024-08-16 15:26:10