PDC na-eburu n'uche njirimara nke ma nnukwu ma obere ụmụ irighiri ihe.Ya mere, in vitro ADME nyocha na ya kwesịrị iburu n'uche peptides homing, ndị na-ejikọ ọnụ, ndị na-akwụ ụgwọ na PDC.N'oge mmalite nke mmepe ọgwụ, ọ bụrụ na peptide homing dị n'ụdị ọgwụ polypeptide, ọ na-adịkarị mfe hydrolysis ma nwee nkwụsi ike na-adịghị mma. Ekwesịrị ịtụle nkwụsi ike ya na ebumnuche ya na plasma; n'otu oge ahụ, ụdị abụọ nke njikọ ahụ ga-emepụta ihe dị iche iche nke metabolic, na ụgwọ a na-akwụ ụgwọ (gụnyere ụgwọ a na-ejikọta na otu akụkụ nke njikọ) bụ obere ọgwụ cytotoxic molecule. Ọ dị mkpa iji chọpụta metabolites nke ọgwụ ndị a maka mmepe ọgwụ. Ya mere, PDC nke mejupụtara peptides homing, njikọ njikọ, na ụgwọ ọrụ kwesịrị ka a mụọ ya na nkwụsi ike plasma, njikọ protein plasma, njirimara metabolite, wdg, nke dị oke mkpa maka mmalite mmalite nke ọgwụ PDC!
Ngwọta ngwaahịa IPHASE "Otu - nkwụsị" maka nyocha in vitro DMPK
Dị ka onye ndu in vitro research bio reagents, IPHASE na-agbaso ụzọ mmalite nke mmepe ọgwụ wee mepụta ụdị dị iche iche nke in vitro biological reagents n'ọtụtụ ọkwa na ubi na-ezubere ntụzịaka nyocha in vitro DMPK nke ọgwụ PDC iji nyere aka nyocha mmepe ọgwụ PDC!
1.Subcellular irighiri reagents
·Microsomes imeju ·Imeju S9/Acidified Imeju S9
·cytosol imeju ·Akụrụ S9
·Lysosome Acidified imeju homogenate
2.Primary Hepatocyte Ngwaahịa
Mmadụ/enwe/Nkịta/Oké/ Òké/Minipig kwụsịtụrụ/Adherent PrimaryHepatocytes
3.Transport Products
Ndị njem ezinụlọ ABC ·SLCndị njem ezinụlọ
4.Recombinant enzyme ngwaahịa
·CYP ·UGT
5.Plasma metụtara ngwaahịa
Ngwaọrụ dialysis nha nhata · Ngwaahịa nkwụsi ike Plasma
Ihe na-ejikọ protein plasma
6.Blank biological matrix
Oge nzipu: 2024-08-16 15:26:10