PDC yayi la'akari da halayen duka manya da ƙananan kwayoyin halitta.Saboda haka, in vitro ADME bincike akan shi yana buƙatar yin la'akari da peptides na homing, masu haɗin gwiwa, abubuwan biya, da PDC.A cikin matakan farko na ci gaban miyagun ƙwayoyi, idan peptide homing yana cikin nau'in maganin polypeptide, yana da haɗari ga hydrolysis kuma yana da rashin kwanciyar hankali. Ya kamata a yi la'akari da kwanciyar hankali da niyya a cikin plasma; a lokaci guda, nau'i biyu na mahaɗin za su haifar da sakamako daban-daban na rayuwa, kuma nauyin da aka saki (ciki har da nauyin da aka haɗa da sashi ɗaya na mahaɗin) wani ƙananan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ce. Yana da mahimmanci don ƙayyade metabolites na waɗannan magunguna don haɓakar ƙwayoyi. Sabili da haka, PDC wanda ya ƙunshi peptides na homing, masu haɗin gwiwa, da masu biyan kuɗi suna buƙatar yin nazari a cikin kwanciyar hankali na plasma, haɗin furotin na plasma, ganewar metabolite, da dai sauransu, wanda ke da mahimmanci ga farkon ci gaban PDC magunguna!
IPHASE "Daya - Tsayawa" Maganin samfur don bincike na DMPK in vitro
A matsayin jagora a cikin in vitro bincike nazarin halittu reagents, IPHASE bi sahun gaba na miyagun ƙwayoyi ci gaban da kuma tasowa da dama in vitro nazarin halittu reagents a mahara matakan da filayen niyya da in vitro DMPK bincike shugabanci na PDC kwayoyi don taimaka PDC miyagun ƙwayoyi ci gaban bincike!
1.Subcellular juzu'i reagents
·Hanta microsomes ·Hanta S9/Acidified Hanta S9
·Hanta cytosol ·Koda S9
·Lysosome · Acidified hanta homogenate
2.Primary Hepatocytes Products
· Mutum/Biri/Kare/Bera/Mouse/An Dakatar Da Minipig/Mai Riko da FiramareHepatocytes
3.Transporter Products
· Masu jigilar iyali ABC ·SLCmasu safarar iyali
4.Recombinant enzyme kayayyakin
·CYP ·UGT
5.Kayayyakin da ke da alaƙa da Plasma
· Na'urorin dialysis ma'auni · Kayan gwajin kwanciyar hankali na Plasma
· Abubuwan da ke daure furotin Plasma
6.Blank nazarin halittu matrix
Lokacin aikawa: 2024-08-16 15:26:10