E amanaʻia e le PDC uiga o moleki tetele ma laiti.O le mea lea, o suʻesuʻega a le ADME in vitro e manaʻomia le amanaʻia o peptides fale, fesoʻotaʻiga, totogi, ma PDC.I le amataga o le atinaʻeina o vailaʻau, afai o le peptide o loʻo i ai i le tulaga o se vailaʻau polypeptide, e faigofie ile hydrolysis ma e le lelei le mautu. O lona mautu ma le taulaʻi ile plasma e tatau ona mafaufauina; i le taimi lava e tasi, o ituaiga e lua o le fesoʻotaʻiga o le a maua ai iʻuga metabolic eseese, ma o le uta tuʻuina atu (e aofia ai le uta e fesoʻotaʻi i le vaega lava e tasi o le fesoʻotaʻiga) o se vailaʻau cytotoxic mole mole laiti. E taua tele le fuafuaina o metabolites o nei vailaʻau mo le atinaʻeina o vailaʻau. O le mea lea, o le PDC e aofia ai peptides, fesoʻotaʻiga, ma uta e manaʻomia ona suʻesuʻeina i le mautu o le plasma, faʻamauina o le protein plasma, faʻamatalaga metabolite, ma isi mea, e taua tele mo le atinaʻeina vave o vailaʻau PDC!
IPHASE "Tasi - taofi" fofo oloa mo su'esu'ega DMPK in vitro
I le avea ai o se taʻitaʻi i in vitro suʻesuʻega biological reagents, IPHASE mulimuli i le pito i luma o le atinaʻeina o vailaʻau ma atinaʻe le tele o in vitro biological reagents i le tele o laʻasaga ma fanua e faʻatatau i le in vitro DMPK suʻesuʻega taʻiala o PDC vailaʻau e fesoasoani i le PDC suʻesuʻega atinaʻe vailaʻau!
1. Subcellular vaega vaega reagents
·Microsomes ate ·ate S9/Acidified Liver S9
·Cytosol ole ate ·Fatugao S9
·Lysosome · Acidified ate homogenate
2. Primary Hepatocyte Products
·Tagata/Mani/Maifau/Iole/Iole/Minipig Fa'agata/Tagata Fa'atonu PrimaryHepatocytes
3. Fela'u oloa
· ABC aiga felauaiga ·SLCfe'avea'i aiga
4.Recombinant enzyme oloa
·CYP ·UGT
5.Plasma oloa faʻatatau
· Equilibrium dialysis masini · Plasma stability test products
· Plasma protein fusifusi reagents
6. Avanoa matrix biological
Taimi meli: 2024-08-16 15:26:10