PDC waxay tixgelisaa astaamaha molekuleyaasha waaweyn iyo kuwa yaryarba.Sidaa daraadeed, @ vitate Cilmi baaris ku saabsan waxay u baahan tahay in lagula xisaabtamo aqalka hantida, isku xirka, mushaharka, iyo PDC.Marxaladaha hore ee horumarka daroogada, haddii peptide peptide uu yahay qaab daawo polypepheptide ah, waxay u nugul tahay hydrolysis oo xasilloon oo liita. Deganaanshadeeda iyo bartilmaameedkeeda ku saabsan plasma waa in la qaddariyo; Isla mar ahaantaana, labada nooc ee isku xirka ayaa soo saari doona natiijooyin dheef-shiid kiimikaad oo kala go 'ah, oo ay ku jiraan mushaharka mushaharka (oo ay ku jiraan mushaharka lagu xirayo isla qaybta isku xirka) waa daroogada' cytotoxic 'oo yar yar. Waa muhiim in la go'aamiyo metabolites ee dawooyinkaas horumarinta daroogada. Sidaa darteed, PDC waxay ka kooban tahay hantida guryaha, xiriiriyeyaasha, iyo culeyska bixinta ayaa loo baahan yahay in lagu baro xasilloonida plasma, aqoonsiga platoin-ka, iwm., Oo ahmiyad weyn u leh horumarinta mukhaadaraadka hore ee PDC!
IPhope "Hal - Jooji" xalka "xalka wax soo saarka ee ku dhaca cilmibaadhista Vittro DMPK Cilmi baarista
Hogaamiye ahaan ku jira vitro cilmi baarista bayoolajiga, iphape wuxuu ku socdaa safka hore ee horumarka daroogada wuxuuna ku yeeshaa retter-ka bayoolojiga ee vittro DMPK ee daroogada PDC-ga si ay u caawiyaan baaritaanka PDC-da ee PDC.
1.subcellular jajab jajab ah
·Murlosomes beerka ·Beerka s9/ Beerka aashitada leh s9
·Beerka cytosol ·Kelyaha S9
·Lysosome · Beedka aashitada anigoorta ah
2. Dib-u-soo-saarka Soo-saarka Hepatocyte
· Bini aadamka / Daanyeerka / Dog / Rat / jiirka / minigig laga joojiyay / sii wadoHepatocytes
3.transporter wax soo saarka
ABC Gaadiidka QARANKA ·SaylGaadiidka Qoyska
4.REZOMBOMSE Alaabada Enzyme
·Syy ·U hant
5. Plaspasasmas Alaabada laxiriirta
· Qalabka Qalabka Qalabka Qalabka
· Plasma protein borotiin ah
6.BLAGBLANT BRIOLE
Waqtiga Post: 2024 - 08 - 16 15:26:10