AMS ule maka n - nitrosamines: na-enyocha mutagenic

Okwu Mmalite nke Amen ule

Nyocha AMEs, nke a makwaara dị ka nje na-eme ka ọ bụrụ nje vioging na-eme ọtụtụ ihe maka ihe omimi nke na-enyocha ọrịa na-enyocha ọrịa kemịkal nke osisi kemịkalụ, gụnyere n - nitrosamines. Ndị Dr. Bruce abụ na 1970s, nnwale a na-eji ụdị nje bactonium nke na-ebute mmụba nke mkpụrụ ndụ ihe nketa. Nnwale ahụ na-ekpebi ma ihe nwere ike ime ka mmụba na DNA nje, na-enye ihe na-egosi na ụmụ mmadụ nwere ike ime.

Gosiputa nke AME NIILE NOT NOM - NITROSAMIS

N - A na-ama nitrosamines maka akụrụngwa ha na-eme, dịka ha nwere ike imebi ihe na-emebi site na nrụgide na nrụgide oxiditive. Ule ames bara uru karịsịa n'ịchọpụta mmetụta ha na-enwe, dị ka ọtụtụ n - Nitrosasanines chọrọ mgbatị eletriki na-emegharị ngwa ngwa na-emekọrịta ihe na DNA. Nke a na - arụ ọrụ na imeju site na imeju P450 enzymes. Iji depụta ntụgharị a metabolic na vitro, a na-eduzi nnwale ahụ ma na-enweghị mgbakọ metabolic site na òtù, nke Mimolian Metabolism ma na-eme ka nchọpụta nke ọrụ mutagolic mee ka ọ bụrụ.

Usoro nke ule aes

Usoro ọkọlọtọ nke ule aes gụnyere usoro ndị a:

1. 1. Nkwadebe nke ngbanwe nnwale: salnonomu typhimuru moturi na premations - mmụba dịnụ na mkpụrụ ndụ ihe nketa Ngwunye ndị a enweghị ike itolite na-enweghị isi mmalite akụkọ mgbe ọ gwụla ma ihe ntụgharị na-eweghachi ọrụ.
2. 2. Ngosiputa na n - Nitrosasamines: A na-agwakọta ọdịbendị nje ya na usoro nnwale (n - nitrosamine) na obere ụlọ ọrụ ochie nwere obere akụkọ.
3. 3. Mweta metabolic (S9 Mix agbakwunye): Accepressfọdụ nlele ụfọdụ na-agụnye s9 microsomes.
4. 4
5. 5. Onu ogugu ogugu na nyocha: ọnụ ọgụgụ nke revonies (nje na-eweghachi ikike iji mepụta akụkọ akụkọ) ma e jiri ya tụnyere efere.
6. Nkọwa nke nsonaazụ

• Nnwale AMEs dị mma: mmụba dị ukwuu na nchịkwa Rebracies ma e jiri ya tụnyere nchịkwa atụnyere mmụba na-egosi mmụba, na-egosi miscinogenic Njirimara Carcinogenic.
• Nnwale AMS: Ọ bụrụ na enweghị mmụba dị egwu, ogige a nwere ike ịbụ na ọ bụghị na-abụghị ọnọdụ ule.
• Dose - Mmekọrịta nzaghachi: elu doses na-eduga na ọnụego mmụba na-ewusi ike na-eme ka ihe àmà nke mutagenidididididididididididididididididididity.

Mmechi

Ule aes bụ ngwa ngwa ma na-eri ego - usoro dị irè maka ịtụle akwara nke n - nitrosamines. Nyere mkpakọrịta ha na ọrịa cancer, na-akọwa ihe ndị na-ahụ maka usoro ha site na nke a n'amaghị ama maka njikwa nchịkwa na nyocha ihe egwu. Ule a ka bụ isi nkuku na nyocha na-enyocha ya na nyocha kemịkalụ.

Keywords: NITROSAMION, NDRIS, OECD 471, Idobe AMES Nnwale, HYTERTE P450 enzymes, ule nyocha