Nhanganyaya kune mrna zvinodhaka
Mutumwa RNA (MrNN) kutevedzana kweNucleotides iyo inoisa mapuroteni, uye mune cytoplasm inokwanisa kushandisa organelles kuratidza protein yakavapo. Mr. Zvinodhaka zvakagadziriswa nemakemikari zvichibva pane kusarudzwa kwechinangwa kana pinda iyo cytoplasm yekufambisa Zvishongedzo MrNA inogona kushandurwa mune chero protein, uye chero zvinodhaka zvinoshandisa mapuroteni sezvinoita marpitiki anogona kutsiviwa nemadzinza ekurapa.
Fig. 1. Zvimiro zveruzivo zvezvinodhaka zvinodhaka uye maitiro ayo anopa basa ravo
Strategies yePharmacokinetic zvidzidzo zve mran zvinodhaka
Pamusoro pekutanga premackinetic kudzidza kwezvinodhaka MrN, zvinogona kukamurwa kuita zvikamu zvitatu zvezvidzidzo zvinoregedza mrnines, MrN Maererano neVa Vaccine - Zvinoenderana neTextelnical Nhungamiro Yakatumirwa naFDA uye Nmpa, Vaccines kazhinji havade maitiro ePermacokinetic, MrNA VACCINES ndeVAKURU DZESVONDO DZINOGONESWA, ZVINODA KUTI BOODIBUAD ZVAKAIPA. Uye iyo pharmacokinetic yekufunda yezvinodhaka zvinodhaka zvinodhaka zvinogona kubatsira kunzwisisa huwandu - maitiro ehukama hwemishonga. Kune mitsva mishonga yekunyepedzera, yakadai semaficic lipids kana zvimwe zvinongedzo muLnp zvinodikanwa zvezvidzidzo zvitsva, muVivo uye neVivoIyo muVitro kudzidza ine metabolic kugadzikana uye metabolite kuzivikanwa kweiyo dzakasiyana masisitimu, uye musiyedzo weVIVO zvine chekunyepedzera, kugoverwa, metabolism uye zvidzidzo zvekunyepedzera mumhuka kuti uone muVivo Adme maitiro eiyo chiitiko. Mushonga - Kubata kwezvinodhaka kweNew Exccivients anoongororwa zvichienderana nedanho rengozi.
Ifase zvigadzirwa zvine chekuita
Mutumwa RNA (MrNN) kutevedzana kweNucleotides iyo inoisa mapuroteni, uye mune cytoplasm inokwanisa kushandisa organelles kuratidza protein yakavapo. Mr. Zvinodhaka zvakagadziriswa nemakemikari zvichibva pane kusarudzwa kwechinangwa kana pinda iyo cytoplasm yekufambisa Zvishongedzo MrNA inogona kushandurwa mune chero protein, uye chero zvinodhaka zvinoshandisa mapuroteni sezvinoita marpitiki anogona kutsiviwa nemadzinza ekurapa.
Fig. 1. Zvimiro zveruzivo zvezvinodhaka zvinodhaka uye maitiro ayo anopa basa ravo
Strategies yePharmacokinetic zvidzidzo zve mran zvinodhaka
Pamusoro pekutanga premackinetic kudzidza kwezvinodhaka MrN, zvinogona kukamurwa kuita zvikamu zvitatu zvezvidzidzo zvinoregedza mrnines, MrN Maererano neVa Vaccine - Zvinoenderana neTextelnical Nhungamiro Yakatumirwa naFDA uye Nmpa, Vaccines kazhinji havade maitiro ePermacokinetic, MrNA VACCINES ndeVAKURU DZESVONDO DZINOGONESWA, ZVINODA KUTI BOODIBUAD ZVAKAIPA. Uye iyo pharmacokinetic yekufunda yezvinodhaka zvinodhaka zvinodhaka zvinogona kubatsira kunzwisisa huwandu - maitiro ehukama hwemishonga. Kune mitsva mishonga yekunyepedzera, yakadai semaficic lipids kana zvimwe zvinongedzo muLnp zvinodikanwa zvezvidzidzo zvitsva, muVivo uye neVivoIyo muVitro kudzidza ine metabolic kugadzikana uye metabolite kuzivikanwa kweiyo dzakasiyana masisitimu, uye musiyedzo weVIVO zvine chekunyepedzera, kugoverwa, metabolism uye zvidzidzo zvekunyepedzera mumhuka kuti uone muVivo Adme maitiro eiyo chiitiko. Mushonga - Kubata kwezvinodhaka kweNew Exccivients anoongororwa zvichienderana nedanho rengozi.
Ifase zvigadzirwa zvine chekuita
| Zvikamu | Kanda |
| Chidimbu chidimbu | chiropa liversome |
| Acidified chiropa homogenate | |
| Chiropa / mumbiri / itsvo / mapapu S9 | |
| Chiropa / dimbina / itsvo / mikwenzi mikrorrosomes | |
| Chiropa / mumbiri / renal / lung cytoplasmic | |
| Primary hepatocytes | Kumiswa Hepatocytes |
| Anotarisirwa Hepatocytes | |
| Exclusive plasma | Plasma Kugadzikana |
| Plasma protein inosunga | |
| Ropa rese | Human / Monkey / Canine / Rat / Mouse / Rabbit / Nguruve Blig Yese Ropa |
Post Nguva: 2024 - 08 - 25 19:54:01