Hordhac Daroogada Mrna
Rasuul RNNA (MRNA) waa isku xigxiga nucleutes-ka ee ku xidhnaa borotiin, iyo cytoplasm-ka waxay awood u leedahay inay u isticmaalaan unugyada loo yaqaan 'diyfelles'. Daawooyinka MRNA-da ayaa si kedis ah wax looga beddelaa iyadoo lagu saleynayo xulashada bartilmaameedyada ama antigens-ka oo ay ku soo galaan nidaamka borotiinka gaarka ah (iyo saaxirku waxay ku dhacdaa in si macquul ah u qaabilsan yahay qolka ka baxsan ama ka dib 1). Fikradaha MRNA waxaa loo tarjumi karaa wax kasta oo borotiin ah, iyo wixii dawooyin ah oo adeegsata borotiinno sida daweynta lagu beddeli karo daweynta MRNA.
Sawir 1
Istaraatiijiyadaha barashada dawooyinka dawooyinka dawooyinka dawooyinka ah ee dawooyinka Mryan
Marka laga hadlayo daraasadda 'parlaninicatic-ka' parkcinetic-ka 'ee daroogada MRNA, waxaa loo qaybin karaa saddex qaybood oo waxbarasho oo lala beegsanayo tallaalada MRNA, MRNAPabaynutiks iyo Proipacicals cusub. Sida ku xusan tallaalka - Tilmaamaha farsamada ee la xiriira ee ay soo saareen FDA iyo NMPA, tallaallada badanaa uma baahna barashada caadiga ah, laakiin qaar ka mid ah tallaallada khaaska ah waa in laga bartaa biodur-ka. Tallaallada MRNA waxay ka tirsan yihiin tallaallo gaar ah, kuwaas oo u baahan waxbarasho bio odomes ah. Iyo daraasadda dawooyinka dawooyinka dawooyinka daweynta ee dawooyinka daweynta ee MRNA waxay gacan ka geysan karaan fahamka tirada - Saamaynta Xiriirka Daroogada. Daawooyinka cusub ee dawooyinka, sida libaaxyada cataliyadu ama maaddooyinka kale ee ku jira nidaamyada gaarsiinta ee LNP waa samafalka cusub ee vivo iyo qiimeynta ku saabsan badbaadada aan dawliga ahayn ee dawooyinka cusub ee dawooyinka cusub ".Waxbarashada vitro-ka waxaa ku jira xasilloonida dheef-shiid kiimikaadka iyo aqoonsashada metabolite ee nidaamyada kala duwanDaraasadda ah ee vivo waxaa ku jira nuugista, qaybinta, dheef-shiid kiimikaad iyo daraasado aan caadi ahayn oo xayawaan ah si loo go'aamiyo habka loo yaqaan 'vipo' vipent of versipent. Dawooyinka - Is dhexgalka maandooriyaha ee samaynta cusubi waa la baarayaa iyadoo kuxiran heerka halista.
Alaabada laxiriira ee iPhepape
Rasuul RNNA (MRNA) waa isku xigxiga nucleutes-ka ee ku xidhnaa borotiin, iyo cytoplasm-ka waxay awood u leedahay inay u isticmaalaan unugyada loo yaqaan 'diyfelles'. Daawooyinka MRNA-da ayaa si kedis ah wax looga beddelaa iyadoo lagu saleynayo xulashada bartilmaameedyada ama antigens-ka oo ay ku soo galaan nidaamka borotiinka gaarka ah (iyo saaxirku waxay ku dhacdaa in si macquul ah u qaabilsan yahay qolka ka baxsan ama ka dib 1). Fikradaha MRNA waxaa loo tarjumi karaa wax kasta oo borotiin ah, iyo wixii dawooyin ah oo adeegsata borotiinno sida daweynta lagu beddeli karo daweynta MRNA.
Sawir 1
Istaraatiijiyadaha barashada dawooyinka dawooyinka dawooyinka dawooyinka ah ee dawooyinka Mryan
Marka laga hadlayo daraasadda 'parlaninicatic-ka' parkcinetic-ka 'ee daroogada MRNA, waxaa loo qaybin karaa saddex qaybood oo waxbarasho oo lala beegsanayo tallaalada MRNA, MRNAPabaynutiks iyo Proipacicals cusub. Sida ku xusan tallaalka - Tilmaamaha farsamada ee la xiriira ee ay soo saareen FDA iyo NMPA, tallaallada badanaa uma baahna barashada caadiga ah, laakiin qaar ka mid ah tallaallada khaaska ah waa in laga bartaa biodur-ka. Tallaallada MRNA waxay ka tirsan yihiin tallaallo gaar ah, kuwaas oo u baahan waxbarasho bio odomes ah. Iyo daraasadda dawooyinka dawooyinka dawooyinka daweynta ee dawooyinka daweynta ee MRNA waxay gacan ka geysan karaan fahamka tirada - Saamaynta Xiriirka Daroogada. Daawooyinka cusub ee dawooyinka, sida libaaxyada cataliyadu ama maaddooyinka kale ee ku jira nidaamyada gaarsiinta ee LNP waa samafalka cusub ee vivo iyo qiimeynta ku saabsan badbaadada aan dawliga ahayn ee dawooyinka cusub ee dawooyinka cusub ".Waxbarashada vitro-ka waxaa ku jira xasilloonida dheef-shiid kiimikaadka iyo aqoonsashada metabolite ee nidaamyada kala duwanDaraasadda ah ee vivo waxaa ku jira nuugista, qaybinta, dheef-shiid kiimikaad iyo daraasado aan caadi ahayn oo xayawaan ah si loo go'aamiyo habka loo yaqaan 'vipo' vipent of versipent. Dawooyinka - Is dhexgalka maandooriyaha ee samaynta cusubi waa la baarayaa iyadoo kuxiran heerka halista.
Alaabada laxiriira ee iPhepape
| Qeybaha | Kala-soocidda |
| Jajab hoosaad | beerka lysosome |
| Geerka shiidan ee loo yaqaan 'anitorenate' | |
| Beerka / xiidmaha / kelyaha / sambabada S9 | |
| Beerka beerka / mindhicirka / Kilyaha / Nabadsamaha | |
| Beerka beerka / mindhicirka / kalgacalka / dheecaanka sambabka | |
| Hepatocytes aasaasiga ah | Eryitaannada hepatocytes |
| Plateocytes | |
| Plasma gaar ah | Plasma xasilloonida |
| Plasma borotiinka platein | |
| Dhiiga oo dhan | Bini-aadamka / Daanyeerka / Canine / jiirka / jiirka / bakaylaha / Doofaarka oo bannaan oo dhan |
Waqtiga Post: 2024 - 08 - 25 19 19:54:01