Gabatarwa zuwa magunguna Mrna
Mashaija RNA (Mrna) shine jerin abubuwan nucleotides da ke kafa furotin, kuma a cikin Cytoplasm zai iya amfani da orgelles don bayyana furotin. Mrna magunguna suna da tsari dangane da zabin maƙasudi ko antigens kuma shigar da takamaiman furotin (misali), inda aka samo takamaiman furotin (misali. 1). Za'a iya fassara Mrna a fili a kowane furotin, da duk magunguna waɗanda ke amfani da sunadarai a matsayin masu warkarwa da masu warkarwa.
Fig. 1
Strateungiyoyi don Nazarin Magunguna na Mran magunguna
Dangane da binciken pasclinical pharccastical na magunguna na Mrna, ana iya raba su zuwa sassa uku na binciken rigakafin magungunan Mista. A cewar maganin - Jami'an FDA da NMPa sun ba da izini ta FDA da NCPA, rigakafi yawanci ba za a yi na yau da kullun ba, ya kamata a yi na yau da kullun rigakafin musamman don masu yin rigakafi. Alurar rigakafin mruna suna cikin rigakafin musamman na musamman, waɗanda ke buƙatar karatun masu yawa. Kuma nazarin magunguna na Magunguna na Magunguna na Magunguna na iya taimakawa fahimtar da yawa - tasirin kwayoyi. Don sabon courmaceutical compifis, kamar su cimic lipids ko wasu sinades a cikin tsarin bayarwa na LNP sune sabon companationarfafa miyagun ƙwayoyin cuta na sabon cirewa mai cirewa ".A cikin binciken Vitro ya ƙunshi kwanciyar hankali na rayuwa da kuma gano asalin metabolite na tsarin daban-daban, kuma a cikin binciken VIVO ya ƙunshi sha, rarraba, rarraba metabolism da karatun excreabtion a cikin dabbobi don sanin tsarin a cikin Adm ɗin ADMe na curifi na Vivo. Miyagun ƙwayoyi - Tushen hulɗar sababbin magunguna ana bincika su gwargwadon matakin hadarin.
Kayayyakin Ifason
Mashaija RNA (Mrna) shine jerin abubuwan nucleotides da ke kafa furotin, kuma a cikin Cytoplasm zai iya amfani da orgelles don bayyana furotin. Mrna magunguna suna da tsari dangane da zabin maƙasudi ko antigens kuma shigar da takamaiman furotin (misali), inda aka samo takamaiman furotin (misali. 1). Za'a iya fassara Mrna a fili a kowane furotin, da duk magunguna waɗanda ke amfani da sunadarai a matsayin masu warkarwa da masu warkarwa.
Fig. 1
Strateungiyoyi don Nazarin Magunguna na Mran magunguna
Dangane da binciken pasclinical pharccastical na magunguna na Mrna, ana iya raba su zuwa sassa uku na binciken rigakafin magungunan Mista. A cewar maganin - Jami'an FDA da NMPa sun ba da izini ta FDA da NCPA, rigakafi yawanci ba za a yi na yau da kullun ba, ya kamata a yi na yau da kullun rigakafin musamman don masu yin rigakafi. Alurar rigakafin mruna suna cikin rigakafin musamman na musamman, waɗanda ke buƙatar karatun masu yawa. Kuma nazarin magunguna na Magunguna na Magunguna na Magunguna na iya taimakawa fahimtar da yawa - tasirin kwayoyi. Don sabon courmaceutical compifis, kamar su cimic lipids ko wasu sinades a cikin tsarin bayarwa na LNP sune sabon companationarfafa miyagun ƙwayoyin cuta na sabon cirewa mai cirewa ".A cikin binciken Vitro ya ƙunshi kwanciyar hankali na rayuwa da kuma gano asalin metabolite na tsarin daban-daban, kuma a cikin binciken VIVO ya ƙunshi sha, rarraba, rarraba metabolism da karatun excreabtion a cikin dabbobi don sanin tsarin a cikin Adm ɗin ADMe na curifi na Vivo. Miyagun ƙwayoyi - Tushen hulɗar sababbin magunguna ana bincika su gwargwadon matakin hadarin.
Kayayyakin Ifason
| Kungiyoyi | Rarrabuwa |
| Subcelulular juji | hanta lysosome |
| Actifie hanta homogenate | |
| Hani / hanji / KOKE / LUNGS S9 | |
| His / Injistal / Koda / Tons | |
| Hanta / hanji / na hanci / hunt cytooplasic ruwa | |
| Na farko hepatocytes | Dakatar da Hepatocytes |
| Gidan Hepatocytes | |
| M plasma | Plasma kwanciyar hankali |
| Plasma furotin da ke ɗaure | |
| Gaba daya jini | Dan Adam / Monkey / Canine / bera / linzamin kwamfuta / Rabbit / Rabbit / Alade / Pig Pig Blank Ranin Jini |
Lokaci: 2024 - 08 - 25 19:54:04:01