Nā hopena no ka Vitro Mrna MRNA DREAM FREAMS Metabolism Studies

Hoʻomohala iā Mrna nā lāʻau lapaʻau
ʻO kaʻelele RNA (MRNA) heʻano o nā nucleodides e hoʻopili ana i kahi protein, a i loko o ka cytoplasm e hiki ai ke hoʻohana i nā orglalles e hoʻopili ai i ka mea hoʻopihapiha. ʻO MRNA nā lāʻau lapaʻau i kohoʻia e pili ana i ke kohoʻana i nā pahuhopu a iʻole nā ​​mea hana i hanaʻia ma keʻano he cytoplas. Hiki ke unuhiʻiaʻo Toretically MRNA i kekahi protein, a me nā lāʻau lapaʻau e hoʻohana ai i nā protein e like me nā mea hana e hiki ke hoʻololiʻia e nā traperatics

Fig.

Nā hoʻolālā no nā haʻawina lāʻau lapaʻau o nā lāʻau mran
E pili ana i ka noiʻana o ka lāʻau lapaʻau preclinical o Mrna Studits, hiki iā ia ke hoʻokaʻawale iʻekolu mau'āpana o nā haʻawina Wahi a nā pale lole - Nā Kauka loea e pili ana i ka FDA a me NMPA, e hoʻopaʻa mauʻia nā pale lāʻau lāʻau lapaʻau maʻamau. ʻO MRNA BARCINES no nā hoʻomaha hoʻomaha kūikawā, e pono ai i nā haʻawina biodistribrigation. Aʻo ka noiʻiʻana o ka Pharmacoyetic o Mrna Therapeutic i nā lāʻau lapaʻau hiki ke kōkua i ka hoʻomaopopoʻana i ka nui - No nā mea hoihoi hou e like me nā mea e like me nā mea kūʻai aku e like me nā mea kūʻai akuʻo Vharmaceties hou.Aia i loko o ka noiʻi vitro e pili ana i ka intabolic stability a metabolite i loaʻa i nā'ōnaehana likeʻole, aʻo ka loiloiʻana i loko o Vivo e loaʻa ana, ka hoʻolahaʻana, metabolism a me nā haʻawina excries i nā holoholona e hoʻoholo ai i ke kaʻina hana vivo. ʻO ka lāʻau lapaʻau -ʻO nā lāʻau lapaʻau e pili ana i nā mea hoihoi hou e nānāʻia ma muli o ka pae o ka pilikia.

Nā huahana e pili ana i nā huahana

Nā Koho	Nā Helu
Milicalital breat morction	ola mossome
	ʻO ke kālele cherr icongied
	Nā Life / nāu / nāu / mau kāleka / māmā s9
	Life
	Liver / instestinal / renal / lung cyoplasmic koko
ʻO nā hepatocytes mua	ʻO nā hepatocytes pale
	Nā huapalapala platble
Hana pā	Plasma Stapeath
	Pili paʻa paʻa Pīkōlani Plain
Koko koko	Kanaka / monkey / canline / rain / radio / rabi / brabbit