Mafala Akutoma Nawo a Mrna
Mthenga RNA (MRNA) ndi mndandanda wa ma nucleotide omwe amalongosola mapuloteni, ndipo mu cytoplasm amatha kugwiritsa ntchito mapuloteni osungidwa. Mankhwala a mrna amasinthidwa mosiyanasiyana kutengera zomwe akufuna kapena antigesm ndikulowa ma cytoplasm mwatsatanetsatane (E.G.) Mwachidziwikire mrna amatha kumasuliridwa mu mapuloteni aliwonse, komanso mankhwala aliwonse omwe amagwiritsa ntchito mapuloteni ngati ochita bwino amatha kusintha maluso a MRNA.
Mkuyu. 1. Zojambula za MRNA Mankhwala ndi njira yomwe amagwiritsa ntchito bwino
Njira za pharmacokinetic maphunziro a MRRAN
Ponena za gulu la zophatikizira zamankhwala za MRNA, zitha kugawidwa magawo atatu a maphunziro olozera katemera wa MRNA, MRNA. Malinga ndi katemera - Malangizo okhudzana ndi FDA ndi katemera, katemera nthawi zambiri safuna maphunziro azochitika, koma katemera wapadera wina ayenera kuphunzira bio Malaistation. Katemera wa MRNA ndi katemera wapadera, womwe umafuna maphunziro a biovely. Ndipo mankhwala a pharmacokinetic a MRNA amathandizira kuti amvetsetse kuchuluka kwa mankhwalawa. Kwa zokolola zatsopano za mankhwala, monga mapids a plids kapena zosakaniza zina mu ma pnroceracicals atsopano, mu vivo, mu vivo, mu vivo, ku Vivo, ku Vivo, kusinthidwe kwamankhwala ogwiritsa ntchito mankhwala atsopano ".Phunziro la vitro lili ndi chotsimikizika cha metabolic ndi metabolite madongosolo osiyanasiyana, ndipo mu maphunziro a Vivo ali ndi mayamwa, kagayidwe kazitabolism ndi maphunziro azowunikira mu nyama kuti adziwe momwe ziliri. Mankhwala - Kuyamwa Mankhwala Otsetsereka Kwatsopano kumayesedwa kutengera kuchuluka kwa ngozi.
Zogulitsa zokhudzana ndi Iphase
Mthenga RNA (MRNA) ndi mndandanda wa ma nucleotide omwe amalongosola mapuloteni, ndipo mu cytoplasm amatha kugwiritsa ntchito mapuloteni osungidwa. Mankhwala a mrna amasinthidwa mosiyanasiyana kutengera zomwe akufuna kapena antigesm ndikulowa ma cytoplasm mwatsatanetsatane (E.G.) Mwachidziwikire mrna amatha kumasuliridwa mu mapuloteni aliwonse, komanso mankhwala aliwonse omwe amagwiritsa ntchito mapuloteni ngati ochita bwino amatha kusintha maluso a MRNA.
Mkuyu. 1. Zojambula za MRNA Mankhwala ndi njira yomwe amagwiritsa ntchito bwino
Njira za pharmacokinetic maphunziro a MRRAN
Ponena za gulu la zophatikizira zamankhwala za MRNA, zitha kugawidwa magawo atatu a maphunziro olozera katemera wa MRNA, MRNA. Malinga ndi katemera - Malangizo okhudzana ndi FDA ndi katemera, katemera nthawi zambiri safuna maphunziro azochitika, koma katemera wapadera wina ayenera kuphunzira bio Malaistation. Katemera wa MRNA ndi katemera wapadera, womwe umafuna maphunziro a biovely. Ndipo mankhwala a pharmacokinetic a MRNA amathandizira kuti amvetsetse kuchuluka kwa mankhwalawa. Kwa zokolola zatsopano za mankhwala, monga mapids a plids kapena zosakaniza zina mu ma pnroceracicals atsopano, mu vivo, mu vivo, mu vivo, ku Vivo, ku Vivo, kusinthidwe kwamankhwala ogwiritsa ntchito mankhwala atsopano ".Phunziro la vitro lili ndi chotsimikizika cha metabolic ndi metabolite madongosolo osiyanasiyana, ndipo mu maphunziro a Vivo ali ndi mayamwa, kagayidwe kazitabolism ndi maphunziro azowunikira mu nyama kuti adziwe momwe ziliri. Mankhwala - Kuyamwa Mankhwala Otsetsereka Kwatsopano kumayesedwa kutengera kuchuluka kwa ngozi.
Zogulitsa zokhudzana ndi Iphase
| Magulu | Kuchuluka |
| Kachigawo kakang'ono | chiwindi lysosome |
| Acid chiwindi homogenate | |
| Chiwindi / matumbo / impso / mapapu s9 | |
| Chiwindi / matumbo / impso / mapapo microsomes | |
| Chiwindi / matumbo / aimpso / atatu cytoplasmic madzi | |
| Akuluakulu a hepatocytes | Kuyimitsidwa hepatocytes |
| Masewera a hepatocytes | |
| Plasma wapadera | Plasma kukhazikika |
| Plasma protein kumanga | |
| Mwazi wonse | Hab / nyani / cankene / rat / mbewa / kalulu / nkhumba |
Post Nthawi: 2024 - 08 - 25:54:01