Kenyelletso ea lithethefatsi tsa MRNA
Messenger RNA (rna) ke tatellano ea nucleotide e nang le protheine, mme ka cytoplasm e khona ho sebelisa li-organer ho hlahisa li-orgain. Lithethefatsi tsa lithethefatsi tsa MRNA li fetotsoe ka lik'hemik'hale ho latela khetho ea liphofu kapa li-anigparm tsa sebopeho sa lik'hemik'hale (E. 1). 1). Ka tsela ea 'nete ea hore' nete e ka fetoleloa ka protheine, 'me lithethefatsi life kapa life tse sebelisang liprotheine ha lingaka li ka nkeloa sebaka ke li-apies tsa' nete.
Feiga. 1. Litšobotsi tsa sebopeho sa lithethefatsi tsa MRNA le ts'ebetso eo li sebetsang le eona
Maano a lithuto tsa pharmacokinetic tsa lithethefatsi tsa mran
Mabapi le thuto ea phapanyetsano ea pharmaconeciatic ea li-rarmaconecialic ea lithethefatsi tsa MNANNA Ho latela ente - Litataiso tse amanang le teketso le Nmpa hangata ha li hloke thuto ea tloaelo ea pharrickokitic, empa liente tse khethehileng li lokela ho ithutoa bakeng sa lithupelo tsa phano, empa liente tse ling tse khethehileng li lokela ho ithutoa bakeng sa phallo ea pharriacokinetic, empa liente tse khethehileng li lokela ho ithutoa bakeng sa lithupelo tsa phano, empa liente tse ling tse khethehileng li lokela ho ithutoa bakeng sa li-vadiankoktic tse khethehileng. Litsie tsa Mrina ke tsa enjine e khethehileng, e hlokang lithuto tsa biodristibution. Phatlalatso ea pharmackikoet ea lingaka tsa MRNA Therapeutic e ka thusa ho utloisisa bongata - Sebelisa kamano ea lithethefatsi. Bakeng sa bakhethoa ba likhahla tse ncha tsa meriana, ba joalo ka mealo e meng ka litsamaiso tsa ho tsamaisa tsa LNP ba hlokahala ho latela "litataiso tsa polokeho ea li-gralinical".Boithuto ba vitro bo na le botsitso ba metabolic le boits'oaro ba metabolite ba lits'ebetso tse fapaneng, 'me ho ithuta vivo ho na le monyaka le ho ithuta metabolism le lithuto tsa ho etsa lipatlisiso tsa liphoofolo tse amohelang tse hloahloa. Lithethefatsi - Tšebelisano ea lithethefatsi ea li-emplity tse ncha e hlahlojoa ho latela boemo ba kotsi.
Lihlahisoa tse amanang le Iphase
Messenger RNA (rna) ke tatellano ea nucleotide e nang le protheine, mme ka cytoplasm e khona ho sebelisa li-organer ho hlahisa li-orgain. Lithethefatsi tsa lithethefatsi tsa MRNA li fetotsoe ka lik'hemik'hale ho latela khetho ea liphofu kapa li-anigparm tsa sebopeho sa lik'hemik'hale (E. 1). 1). Ka tsela ea 'nete ea hore' nete e ka fetoleloa ka protheine, 'me lithethefatsi life kapa life tse sebelisang liprotheine ha lingaka li ka nkeloa sebaka ke li-apies tsa' nete.
Feiga. 1. Litšobotsi tsa sebopeho sa lithethefatsi tsa MRNA le ts'ebetso eo li sebetsang le eona
Maano a lithuto tsa pharmacokinetic tsa lithethefatsi tsa mran
Mabapi le thuto ea phapanyetsano ea pharmaconeciatic ea li-rarmaconecialic ea lithethefatsi tsa MNANNA Ho latela ente - Litataiso tse amanang le teketso le Nmpa hangata ha li hloke thuto ea tloaelo ea pharrickokitic, empa liente tse khethehileng li lokela ho ithutoa bakeng sa lithupelo tsa phano, empa liente tse ling tse khethehileng li lokela ho ithutoa bakeng sa phallo ea pharriacokinetic, empa liente tse khethehileng li lokela ho ithutoa bakeng sa lithupelo tsa phano, empa liente tse ling tse khethehileng li lokela ho ithutoa bakeng sa li-vadiankoktic tse khethehileng. Litsie tsa Mrina ke tsa enjine e khethehileng, e hlokang lithuto tsa biodristibution. Phatlalatso ea pharmackikoet ea lingaka tsa MRNA Therapeutic e ka thusa ho utloisisa bongata - Sebelisa kamano ea lithethefatsi. Bakeng sa bakhethoa ba likhahla tse ncha tsa meriana, ba joalo ka mealo e meng ka litsamaiso tsa ho tsamaisa tsa LNP ba hlokahala ho latela "litataiso tsa polokeho ea li-gralinical".Boithuto ba vitro bo na le botsitso ba metabolic le boits'oaro ba metabolite ba lits'ebetso tse fapaneng, 'me ho ithuta vivo ho na le monyaka le ho ithuta metabolism le lithuto tsa ho etsa lipatlisiso tsa liphoofolo tse amohelang tse hloahloa. Lithethefatsi - Tšebelisano ea lithethefatsi ea li-emplity tse ncha e hlahlojoa ho latela boemo ba kotsi.
Lihlahisoa tse amanang le Iphase
| Mekhahlelo | LITLHAKISO |
| SubNaular ea subdollur | sebete se nyonyehang |
| Homonized ea acidiped | |
| Liver / Milesnes / Lihono / matšoafo a s9 | |
| Liver / Alestinal / Liphio | |
| Liver / Kamessinal / Renal | |
| Litereke tsa mantlha tsa mantlha | Libaka tsa ho emisoa |
| Li-hepatocytes tse ka khonehang | |
| Plasma e ikhethang | Botsitso ba plasma |
| Plasa Protinding | |
| Mali a felletseng | Motho / monkey / canine / mouse / mouse / mmutla / kolobe e se nang letho |
Nako ea poso: 2024 - 08 - 25 19:54:01