Tunda ayyukan miyagun ayyukan enzyme a hankali suka ragu tare da tsawaita lokacin ganowa, karancin karancin ganowa na clint dinka.[1]. A halin yanzu,hefatocytes suna da ƙarin enzymes da ake buƙata don hadawa da hadawa, ragewa, hydrolysis da rage halayen idan aka kwatanta dahanta micosomes, kuma a cikin tsarin vitro, mutane da yawa model na iya inganta su dangane dahefatocyte tsarin da kuma ci gaba da haushi a cikin yanayin vivo don tsawan riƙe da aikin enzyme a cikihefatocytes, da tsawanta lokacin shiryawa yana samar da yiwuwar isa isasan canji na rayuwa-metabolica[1,2].
Ganin wannan, Iphayan, a matsayin jagora a cikin binciken halittu, da kuma tsarin kafofin watsa labarai na Hepatopox an inganta tsarin kafofin watsa labarai na Hepatopox ta amfani da ari na farkohefatocyteS a matsayin misali, kuma duka tsarin an kafa su ne don tabbatar da ayyukan metabolic da kuma karuwa na amsawa a cikin kwanaki 10 da kwana 7 don tabbatar da tsarin. Metabolite yana haɓaka darajar amsa a cikin kwanaki 10 da aiki da kuma kwanciyar hankali na rayuwa na takamaiman nau'in enzyme a cikin kwanaki 7 aka ƙaddara don tabbatar da tsarin.
- (1) Tsarin al'adun ƙwayoyin cuta guda biyu masu tsari sune kamar haka:
Iphayan - Hepatomax ™A CO - tsarin al'adu mai sanyi na daskararre hepatocytes da sel mai tsauri. An yi tauhidi na farko kuma an sanya shi da sel mai tsauri a cikin kwanaki 3 don fara kawai tare da miyagun ƙwayoyi ba tare da canza matsakaici ba. A jimlar 4, 72, 168 da awanni 168 da awanni 240 da awanni 24, da kara darajar miyagun ƙwayoyi aka yanke don bincike.
Iphayan - hepatocon ™, a gefe guda, tsari ne don yin tsirar da daskararru na ɗan adam mai yawa a cikin matsakaiciyar hepatocon ™. Bayan ya sake gyara ainihin ɗan adamhefatocyteS, da aka gudanar da gwamnatin Acsay bayan kwanaki 3 na al'ada a hepatocon ™, da kuma na biyu lokacin gudanar da tsarin na Hepatomax ™.
A halin yanzu, don tabbatar da daidaito da rigakafin sakamakon, Iphayan ya yi aiki na matsakaici (tantanin halitta - kyauta) da kuma sarrafa sel mai ƙarfi a lokaci guda, tare da abubuwan da aka sarrafa su guda uku, kuma sakamakon ya nuna cewaIphayan - Hepatomax ™ daIphayan - hepatocon ™ Tsarin yana samar da ingantaccen abin da ya amsa daga Ranar 3 gaba, kuma dukansu sun nuna karfin farashin canji na rayuwa.
- (2) metabolism metabolism shine yafi dogara da hepatocyteCyp450Tsarin enzyme, kuma ana iya auna shi don mafi kyawun bincike.
DaIphayan - Hepatomax ™ daIphayan - hepatocon ™ Tsarin aiki yana da amfani mai kyau.
Iphayan ya kafa nau'ikan sarrafawa guda huɗu na matsakaici (babu sel), hepatopox ™, sel mai slels. Yin amfani da bango - na farkohefatocyteS a matsayin misali, haɓaka mitabolite naCyp1a2, Cyp2b6daCyp3a4an tabbatar da ranar 0, 3 da 7 bayanhefatocyteSake dawowa tsawon kwanaki 3 ta amfani da finintastastede, cipropion da mitazolam a matsayin mahimmancinsu. Metabolite figewar dabi'u ya nuna cewa duka biyunIphayan - Hepatomax ™ daIphayan - hepatocon ™ Tsarin bincike ya nuna aiki enzyme aiki da rana 7, da kuka inganta metabolism miyagun ƙwayoyi.
- (3) Baya ga ingancin ayyukan enzyme, ingantaccen kwanciyar hankali na rayuwa shima muhimmin mataki ne da kuma m mataki a cikin tabbatar da amfani da amfani a cikin samfurin vitro modle.
Iphayan sun kafa nau'ikan Hepatomahefatocytes, kuma sakamakon ya nuna cewa duka biyunIphayan - Hepatomax ™ daIphayan - hepatocon ™ Tsarin duka ya nuna cewa yana ba da haske tsakanin aikin ci gaba na rayuwa a cikin mafi tsayi na lokacin ass.
A cikin Takaitawa, Iphayan, a matsayin jagora a cikin Cikin Bio Bio - Reagents, ya ingantaIphayan Hepatomax ™ daHepatocatocon ™ A cikin samfurin vitro na tushen bango - Aiwatar da ɗan adam, biri, Canine, bera da linzamin kwamfutahefatocyteS da sel masu sel iri daban-daban na Genera, tare da kyawawan ayyukan Enabolic da ƙarfi, kuma ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan iko ne don tabbatar da gano abubuwan ƙwayoyi! DaIphayan Hepatomax ™ daHepatocatocon ™ A cikin samfuran vitro na ba da kyakkyawan tsari na lokaci-lokaci na rayuwa, ayyukan enzyme masu ƙarfi, suna samar da sabbin abubuwa don ganowa!
Tunani:
[1] 阮婷婷, 鞠武建, 熊海伟, 等. 低清除率药物 的 的 [j] .., 2019 (2): 152 - 160.
[2] Di L, Trapa P, Obach R S, et al. Hanyar ba da labari ba don tantance low ba - Tsararren ƙimar [J]. Magungun metabolism da kuma yanayin, 2012, 40 (9): 1860 - 1865.
Lokacin Post: 2024 - 19 17:20:41